IMMP2L Antibody

說明書

中文名稱：

IMMP2L兔多克隆抗體
貨號：

CSB-PA822306ESR1HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA822306ESR1HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) IMMP2L Polyclonal antibody
Uniprot No.：

Q96T52
基因名：

IMMP2L
別名：

IMMP2L; Mitochondrial inner membrane protease subunit 2; IMP2-like protein
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Mitochondrial inner membrane protease subunit 2 protein (1-100AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
基因功能參考文獻：
1. While the IMMP2L deletions carried non-recurrent breakpoints, in contrast to previous reports, meta-analysis found no evidence of association (P > 0.05) between IMMP2L deletions and ASD. We also observed common exonic deletions impacting IMMP2L in a separate control (5,971 samples) cohort where subjects were screened for psychiatric conditions. PMID: 29152845
2. data would indicate that deletions involving the IMMP2L gene may contribute to the development of a subgroup of cognitive/behavioral disorders PMID: 29788020
3. Deficiency of IMMP2L in cells cultured under hypoxia and high glucose, exacerbated neuronal death. PMID: 28316022
4. Chromosomal breakpoints involved the IMMP2L gene in 7q31 is associated with Diffuse Large B-Cell Lymphomas. PMID: 27356265
5. IMMP2L transcription requires Topoisomerase I in human primary astrocytes PMID: 27932244
6. genomic rearrangements affecting IMMP2L may be one of the predisposing factors involved in Tourette syndrome and overlapping neurodevelopmental disorders. PMID: 24549057
7. AUTS1/AUTS5 linkage to immp2l-dock4 may be involved in autism susceptibility PMID: 19401682
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相關疾病：

Gilles de la Tourette syndrome (GTS)
亞細胞定位：

Mitochondrion inner membrane; Single-pass membrane protein.
蛋白家族：

Peptidase S26 family, IMP2 subfamily
組織特異性：

Expressed in all tissues tested except adult liver and lung.
數(shù)據(jù)庫鏈接：

HGNC: 14598

OMIM: 137580

KEGG: hsa:83943

STRING: 9606.ENSP00000329553

UniGene: Hs.655722

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