IL2RB (Ab-364) Antibody
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中文名稱：IL2RB (Ab-364)兔多克隆抗體
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貨號：CSB-PA832482
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規格：￥2024
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圖片：
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Western blot analysis of extracts from COS7 cells, using IL-2Rβ/CD122 (Ab-364) antibody. -
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using IL-2Rβ/CD122 (Ab-364) antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) IL2RB Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：IL2RB; IL15RB; Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; Interleukin-15 receptor subunit beta; p70-75; p75; CD antigen CD122
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized non-phosphopeptide derived from Human IL-2Rβ/CD122 around the phosphorylation site of tyrosine 364 (Q-G-Y(p)-F-F).
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:200 IF 1:100-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
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基因功能參考文獻：
- Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2- and IL-15-activated T-cells has been reported. PMID: 27463037
- An association with the risk of erosion was observed for a haplotype of 2 single nucleotide polymorphisms of the IL-2RB gene in ACPA positive Rheumatoid arthritis patients. PMID: 26203933
- CD112 downregulation resulted in a reduced ability of DNAM-1 to bind to the surface of both virus-infected and gD-transfected cells. PMID: 25352670
- IL-2 receptor beta chain expression is drastically diminished on T cells in ANCA-associated vasculitis. PMID: 24648606
- in anti-citrullinated protein antibody positive rheumatoid arthritis, the haplotype AC of IL-2RB was associated with a higher rate of erosions at baseline and at 1 year follow-up in comparison to other haplotypes. PMID: 24200909
- This is the first report demonstrating that heterodimeric combinations of IL-2R and IL-6R subunits are functional for signaling. PMID: 23926072
- MiniSTR marker D22S1045 (locus 22q12.3) is localized near the breakpoint region of the Ewing Sarcoma gene, but was found to be neutral related to EWS in a case-control study analyzing allele frequencies and linkage disequilibrium. PMID: 24112992
- Suggest that oxalate-induced activation of the renal IL-2Rbeta pathway may lead to a plethora of cellular changes, the most common of which is the induction of inflammation. PMID: 24523387
- Data indicate that both CgammaCR-CD127(+)composed of Interleukin-7 (IL-7) tethered to IL-7Ralpha/CD127, and CgammaCR-CD122(+) CD8(+) T((E/CM)) engraft in mice and persist in an absence of exogenous cytokine administration. PMID: 23628622
- Data suggest that cross-talk occurs between cAMP/PKA and the IL-2R beta/Jak3/Stat5b cascade in T-cells. PMID: 23341462
- Single nucleotide polymorphism in IL2RB is associated with lung cancer. PMID: 22573796
- The researchers found evidence that there were significant differences between the D22S1045 locus in the Maghreb population and other populations. PMID: 21674833
- Genetic variants of IL2RB may be associated with the development of acute rejection episodes and may help predict risk in kidney transplantation patients. PMID: 21839273
- LTR of the THE1D retroelement family has been domesticated as an alternative promoter of human IL2RB, the gene encoding the beta subunit of the IL-2 receptor. PMID: 21865161
- Lyn coimmunoprecipitates with the interleukin-2 beta receptor and JAK3 proteins in human T-cell leukemia virus type 1-infected T-cells. PMID: 21345943
- IL-15R alpha, which bears most of the binding affinity for IL-15, behaves as a potent IL-15 agonist by enhancing its binding and biological effects through the IL-15R beta/gamma heterodimer. PMID: 16284400
- Data show that co-expression of ZNF300 and Egr1 lead to enhanced IL-2Rbeta promoter activity, and suggest that ZNF300 is another regulator of the human IL-2Rbeta promoter. PMID: 20585888
- IL-2Rbeta is subject to ectodomain shedding generating an intracellular fragment biologically functional, because (i) it is phosphorylated, (ii) it associates with STAT5A, and (iii) it increases cell proliferation. PMID: 20495002
- Alternate signalling pathways from the interleukin-2 receptor PMID: 11750878
- Here we show, in four cell lines of human adult T cell lymphoma/leukemia origin, that the three IL-2R subunits are compartmented together with HLA glycoproteins and CD48 molecules in the plasma membrane PMID: 11856346
- SHB links IL2 receptor for signal transduction and mediates apoptosis PMID: 12200137
- Peptide p1-30, which is composed of the 30 amino-terminal residues of human interleukin-2, binds as a tetramer to the dimeric IL-2Rbeta2 receptor PMID: 12676936
- The development of breast tumour is associated with an increased expression of IL-2 receptor beta and this expression also seems to be associated with the malignancy of the tumour. PMID: 14680494
- Cultures in the presence of peptide epitopes to this receptor inhibited T cell proliferation. PMID: 15350462
- Interleukin-2 receptor beta-627*C homozygote and C allele correlate with higher susceptibility to endometriosis. PMID: 16084898
- location of the G245R polymorphism next to the proximal cytokine receptor homology segment; suggestive of a genetic association with the development of visceral leishmaniasis. PMID: 17108990
- these results indicate that precise sorting of IL-2Rbeta from early to late endosomes is mediated by Hrs, a known sorting component of the ubiquitin-dependent machinery, in a manner that is independent of UIM-ubiquitin binding PMID: 18445679
- study found PI3K & STAT5 signaling pathways are required for granulysin expression & IL-2Rbeta induction & IL-2Rbeta induction is a prerequisite for granulysin expression; both signaling pathways are defective in CD4+ T cells from HIV-infected patients PMID: 18490721
- Report the selective expansion of genetically modified T cells using an antibody/IL2RB receptor chimera. PMID: 18589435
- High serum IL-2R level is associated with peripheral T-cell lymphoma, unspecified. PMID: 18592269
- The uncleaved 12-kDa form of p12(I) resides in the ER and interacts with the beta and gamma(c) chains of the interleukin-2 receptor (IL-2R), the heavy chain of the major histocompatibility complex (MHC) class I, as well as calreticulin and calnexin. PMID: 18791162
- the preformed complexes between gamma c and IL-2Rbeta or IL-9Ralpha promote signaling by the JAK3 A572V mutant without ligand, identified in several human cancers. PMID: 18829468
- The C627T polymorphism in the IL2RB gene is not associated with risk of endometriosis in Korean women. PMID: 19602517
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亞細胞定位：Cell membrane; Single-pass type I membrane protein.
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蛋白家族：Type I cytokine receptor family, Type 4 subfamily
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