IL21R Antibody

說明書

中文名稱：

IL21R兔多克隆抗體
貨號：

CSB-PA443269
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA443269(IL21R Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA443269(IL21R Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9HBE5
基因名：

IL21R
別名：

CD360 antibody; IL 21R antibody; IL-21 receptor antibody; IL-21R antibody; IL21 receptor antibody; IL21R antibody; IL21R_HUMAN antibody; Interleukin 21 receptor antibody; Interleukin-21 receptor antibody; MGC10967 antibody; NILR antibody; Novel interleukin receptor antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human IL21R
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

This is a receptor for interleukin-21.
基因功能參考文獻：
1. The number of IL-2-dependent FoxP3(+) regulatory T cells is increased in the peripheral blood of human patients with loss-of-function mutations in the IL-21 receptor (IL-21R). PMID: 28303891
2. bone marrow monocytes from multiple myeloma patients show distinct features compared to those from patients with indolent monoclonal gammopathies, supporting the role of IL21R over-expression by bone marrow CD14(+) cells in enhanced osteoclast formation. PMID: 28057743
3. Report increased levels of IL-21R in the skeletal muscle endothelial cells of patients with peripheral arterial disease compared to control individuals. PMID: 26705256
4. expression of IL-21 and IL-21R were up-regulated in autoimmune thyroid disease and may be involved in the pathogenesis of the disease through augmenting aberrant immune cascade PMID: 25647271
5. interleukin-21 receptor deficiency is associated with Severe Combined Immunodeficiency. PMID: 25398835
6. IL-21R on B cells is upregulated in allergic rhinitis patients when compared to controls. IL-21/IL-21R may be involved in the regulation of allergic reactions through the inhibition of IgE. PMID: 25007029
7. IL-21/IL-21R could act as potential biomarkers presenting early systemic sclerosis skin lesions severity. PMID: 25500255
8. STAT3 signaling downstream of IL-23R and IL-21R has a role in controlling human mucosal-associated invariant T cells and NKT cell numbers PMID: 25941256
9. Human neutrophils in peripheral blood express functional IL-21 receptors. PMID: 24728504
10. IL-21R gene polymorphisms and serum IL-21 levels predict virological response to interferon-based therapy in Asian chronic hepatitis C patients. PMID: 23296193
11. Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease. PMID: 23098230
12. Data suggest that IL21 rs2221903 and IL21R rs3093301 polymorphisms may, independently or interactively, affect the susceptibility to and/or persistence of HBV infection potentially through altering IL-21 and IgE production. PMID: 23354321
13. The IL-21R/STAT3 pathway is required for many aspects of human CD8(+) T-cell behavior but in some cases can be compensated by other signals. PMID: 23830147
14. Human monocyte-like THP-1 cells express two IL-21 receptor components, CD132 (gammac) and IL-21Ralpha, on their cell surface, as assessed by flow cytometry. PMID: 23396946
15. human IL-21R deficiency causes an immunodeficiency and highlights the need for early diagnosis PMID: 23440042
16. For risk-factor studies, anti-citrullinated peptide antibody-positive (CCP)-negative rheumatoid arthritis patients can be studied as one group via measurement of their IL-21 and IL-21 receptor levels. PMID: 22032620
17. Crystal structure of IL-21 binding to IL-21R reveals that the WSXWS motif of IL-21R is C-mannosylated at the first tryptophan. PMID: 22235133
18. IL21R and vezatin were also cleaved in apoptotic HeLa cells with the cleavage sites Asp344, Asp655 and Asp53. PMID: 21524651
19. Data suggest that the association of 2009 H1N1 vaccine-induced Ab responses with IL-21/IL-21R upregulation and with development of memory B cells and plasmablasts has implications for future research in vaccine design. PMID: 21531891
20. These findings suggest role(s) for IL-21 in both the acute and chronic stages of multiple sclerosis via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons. PMID: 21281812
21. parathyroid hormone (PTH) and interleukin 21 receptor (IL21R), achieved consistent association results for bone mineral density in both discovery and replication samples. PMID: 19874204
22. IL-21R is expressed in follicular lymphoma cells from early diagnosed, untreated patients. It mediates apoptosis. It is heterogenously expressed by human FL cell lines bearing the t(14;18) translocation. PMID: 20193734
23. This report provides the first evidence that WSB-2 is a regulator of IL-21R expression and IL-21-induced signal transduction. PMID: 20059963
24. IL-21R is associated with the activated phenotype of rheumatoid arthritis synovial fibroblasts independently of the major proinflammatory cytokines IL-1beta and TNFalpha, but not with the destruction of articular cartilage and bone. PMID: 15146416
25. The up-regulation of IL-21R in keratinocytes indicates that its expression pattern is not only altered but it appears to be independent of key cytokines that are operant in systemic scleosis. PMID: 15751077
26. TCR-induced IL-21R expression is driven by TCR-mediated augmentation of Sp1 protein levels and may partly depend on the dephosphorylation of Sp1 PMID: 16260592
27. surface IL-21 receptor is expressed at variable levels by chronic lymphocytic leukemia B cells PMID: 16391014
28. IL-21 differentially regulates IL-4-induced IgE production, via its growth- and differentiation-promoting capacities on isotype- committed B cells, & via its ability to induce IFNg production; the outcome depends on the presence of a IL-21R polymorphism. PMID: 17015683
29. IL-21R is overexpressed in the inflamed synovial membrane and in peripheral blood or synovial fluid leukocytes of RA patients. Thus, blockade of IL-21R signalling pathway may have a therapeutic potential in acute RA patients. PMID: 17032244
30. Data suggest a contribution of IL21 and IL21R to genetic susceptibility to type 1 diabetes and possible involvement of IL-21 and its receptor system in the disease pathogenesis. PMID: 17462506
31. Follicular lymphoma cells showed exceptionally high IL-21R expression. IL-21 induced apoptosis in follicular lymphoma cells expressing high levels of IL-21 receptor. PMID: 17624663
32. These results suggest an important role for IL-21R in the mobilization of skin dendritic cells to draining lymph nodes and the subsequent allergic response to epicutaneously introduced antigen. PMID: 19075398
33. analyzed the transcriptional differences between B-cell subsets by gene expression profiling, and identified 15 genes significantly correlated to survival/proliferation. Among them, IL-21R and TCL1 were highly expressed in naive B cells. PMID: 19230867
34. Increased IL-21R is associated with inflammatory bowel disease. PMID: 19322899
35. Tax1 transactivates the interleukin-21 (IL-21) and its receptor (IL-21R) genes in human T-cells. PMID: 19617351
36. A polymorphism within IL21R confers risk for systemic lupus erythematosus. PMID: 19644854
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相關疾病：

IL21R immunodeficiency (IL21RID)
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Type I cytokine receptor family, Type 4 subfamily
組織特異性：

Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
數據庫鏈接：

HGNC: 6006

OMIM: 605383

KEGG: hsa:50615

STRING: 9606.ENSP00000338010

UniGene: Hs.210546

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