IL1RL2 Antibody, FITC conjugated
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中文名稱：IL1RL2兔多克隆抗體, FITC偶聯
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貨號：CSB-PA888016LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) IL1RL2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：IL 1 receptor related protein 2 antibody; IL 1Rrp2 antibody; IL 36R antibody; IL-1Rrp2 antibody; IL-36 receptor antibody; IL1 receptor related protein 2 antibody; IL1R rp2 antibody; IL1R-rp2 antibody; Il1rl2 antibody; IL1RRP2 antibody; IL36R antibody; ILRL2_HUMAN antibody; Interleukin 1 receptor like 2 antibody; Interleukin 1 receptor related protein 2 antibody; Interleukin-1 receptor-like 2 antibody; Interleukin-1 receptor-related protein 2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Interleukin-1 receptor-like 2 protein (20-218AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
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基因功能參考文獻：
- Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor. PMID: 27673278
- All human blood lymphocytes express IL-36R. PMID: 27269181
- The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention. PMID: 26813344
- single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043
- The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response. PMID: 27853811
- The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R. PMID: 26269592
- IL36A-IL36R axis is modulated in patients with primary Sjogren's syndrome. PMID: 25902739
- Expression of IL-1Rrp2 by sone dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 lymphocytes. PMID: 22144259
- These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422
- IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry PMID: 16546408
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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蛋白家族：Interleukin-1 receptor family
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組織特異性：Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
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數據庫鏈接：
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