IGFBP6 Antibody, FITC conjugated
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中文名稱：IGFBP6兔多克隆抗體, FITC偶聯
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貨號：CSB-PA011100LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) IGFBP6 Polyclonal antibody
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Uniprot No.：
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基因名：IGFBP6
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別名：IBP 6 antibody; IBP-6 antibody; IBP6 antibody; IBP6_HUMAN antibody; IGF binding protein 6 antibody; IGF-binding protein 6 antibody; IGFBP 6 antibody; IGFBP-6 antibody; IGFBP6 antibody; Insulin like growth factor binding protein 6 antibody; Insulin-like growth factor-binding protein 6 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Insulin-like growth factor-binding protein 6 protein (32-161AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.
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基因功能參考文獻：
- A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug. PMID: 29577195
- IGFBP-6 could inhibit invasion and migration of colorectal carcinoma cells PMID: 29439316
- IGFBP6 might be an important regulator and prognostic factor for glioma. PMID: 27650075
- Results suggest that insulin like growth factor binding protein 6 (IGFBP6) may be an independent prognostic biomarker for nasopharyngeal carcinoma (NPC). PMID: 27623076
- We identified a novel SNP variant, Chr12:g.53494591T>C. c.T430C (p.S144P) in the insulin-like growth factor binding protein-6 (IGFBP6) gene. This variant was shared by all affected family members, but not by unaffected members. The c.T430C (p.S144P) variant of IGFBP6 was identified as the likely causal variant associated with increased risk of familial disc degeneration in the studied pedigree. PMID: 28829625
- We found that IGFBP6 and SATB2 were significantly down-regulated in HIV-infected CEM*174 cells and 3 different cohorts of HIV/AIDS patients while their promoters were predominantly hyper-methylated compared with normal controls. PMID: 26039376
- IGFBP6 attenuation in ACTH-secreting pituitary adenomas is associated with tumor growth, through activation of PI3K-AKT-mTOR pathway PMID: 24379119
- CCL-18 and IGFBP-6 were identified as new potential serum biomarkers for prostate cancer. PMID: 24747338
- When the concentrations of IGFBP-6 or KNG1 were greater than 98.5 pg/ml or 88.5 ng/ml, respectively, they predicted the proliferative vitreoretinopathy prognosis. PMID: 23808406
- Data indicate that IGFBP-6 binds to prohibitin-2 on the cell membrane, and knockdown of the latter abrogates IGFBP-6-induced migration. PMID: 24003225
- Review of the IGF system in physiology and disease with a focus on the regulation and actions of IGFBP-6, and its potential roles in cancer cells. PMID: 23126425
- These results suggest that the expression of IGFBP-6 in vascular endothelial cells is up-regulated by hypoxia and IGFBP-6 inhibits angiogenesis in vitro and in vivo PMID: 21618524
- IGFBP-6 acts as a inhibitory mediator of thyroid hormone effects in osteoblast differentiation PMID: 21997736
- TCDD at low concentrations may have a negative effect on cell apoptosis and down-regulate gene expression of IGFBP-6 in SaOS-2 cells. PMID: 18724896
- Hh pathway is aberrant activation in colorectal carcinoma cell line. Its inhibitor may be effectual agent for colorectal cancer chemoprevention. Gli1 maintained cell survival by binding promoter regions and facilitating transcription of IGFBP6 and Bcl-2. PMID: 21940310
- When IGFBP-6 gene expression was downregulated, cell proliferation was inhibited and apoptotic cell death was increased. PMID: 21820463
- Kininogen-1 and IGFBP-6 are expressed in serum and vitreous humor in proliferative vitreoretinopathy patients. PMID: 21054968
- IGFBP-6 inhibits osteoblastic differentiation mediated by vitamin d3 by directly binding the vitamin d receptor and inhibiting its function PMID: 21458526
- These results indicate that IGFBP-6 promotes Rh30 rhabdomyosarcoma chemotaxis in an IGF-independent manner, and that MAPK signaling pathways and their cross-talk play an important role in this process. PMID: 20432455
- Inhibition of human osteoblast marker gene expression by retinoids is mediated in part by insulin-like growth factor binding protein-6. PMID: 11914024
- may function as an antiproliferative molecule suppressing mitogenic effects of insulin-like growth factors on Malassez cells PMID: 12558805
- CCI-779 acts additively with IGFBP-6 to reduce rhabdomyosarcoma growth both in vitro and in vivo. PMID: 14710364
- C-domain of IGFBP-6 consists of a thyroglobulin type 1 fold comprising an alpha-helix followed by a loop, a three-stranded antiparallel beta-sheet incorporating a second loop, and a disulfide-bonded flexible third loop. PMID: 15308688
- A close correlation exists between residues of the carboxyl-terminal domain of IGFBP6 undergoing conformational change in 15N NMR spectroscopy studies with those that disappeared or broadened upon insulin-like growth factor (IGF-II) binding. PMID: 15366928
- The IGFBP-6 protein is synthesized as propeptides with a hydrophobic leader sequence, removal of which yields a mature protein composed of 3 recognizable domains of similar size. PMID: 15797461
- transgenic human IGFBP-6 mice may be considered a new tool for studies of the involvement of the brain IGF system in metabolism control and obesity. PMID: 15889232
- p38 MAPK is involved in IGFBP-6-induced IGF-independent rhabdomyosarcoma cell migration PMID: 17519236
- Toxic effect of TCDD on osteogenesis through altering IGFBP6 gene expression in osteoblasts is reported. PMID: 17978469
- IGFBP-6 is translocated to the nucleus with functional consequences, and different members of the IGFBP family have specific nuclear import mechanisms. PMID: 18039785
- These studies provide evidence that overexpression of IGFBP-6 suppresses human and murine osteoblast differentiation, that IGFBP-6 and LMP-1 physically interact, and supports the conclusion that this interaction may be functionally relevant. PMID: 18395833
- bexarotene increased the occupancy of the identified enhancer element in IGFBP-6 gene by RXRalpha, RARbeta, cJun, cFos, and p300 PMID: 18957410
- Data show that an increase in JNK activation in the presence of NFkappaB inhibition significantly increased the expression of IGFBP6. PMID: 18982452
- IGFBP-6 is the effector of tumor suppressor activity of SEMA3B. PMID: 18985860
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亞細胞定位：Secreted.
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