ICAM2 Antibody
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中文名稱(chēng)：ICAM2兔多克隆抗體
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貨號(hào)：CSB-PA009375
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of 3T3 cells using ICAM-2 Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：ICAM2; Intercellular adhesion molecule 2; ICAM-2; CD antigen CD102
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human ICAM-2.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點(diǎn)詳情
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功能：ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
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基因功能參考文獻(xiàn)：
- Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. PMID: 29671117
- ICAM2 induction by p53 has a key role in inhibiting cancer cell migration and invasion.ICAM2 acts at least in part through the suppression of the MEK-ERK signaling pathway. PMID: 27556181
- INDEED also identified some candidates previously reported to be relevant to HCC, such as intercellular adhesion molecule 2 (ICAM2) and c4b-binding protein alpha chain (C4BPA), which were missed by both Differential expression and differential network analyses PMID: 27592383
- Both ICAM-2 and ICAM-1 levels in plasma were markedly increased in Ankylosing Spondylitis Chinese patients compared to controls. PMID: 26641849
- Soluble ICAM2 was higher in ADHD patients than in controls. PMID: 26377944
- Results indicate that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediated non-metastatic phenotype in neuroblastoma cells. PMID: 24704826
- with larger patient groups and preferably detailed histopathological and clinical evaluations, are needed to explain the severity of ICAM-1, ICAM-2, and ICAM-3 molecules in Barrett's esophagus PMID: 24474251
- ICAM-2 was significantly more pronounced in plasma cell mastitis than in nonpathologic breast tissue. However, no significant differences in ICAM-2 immunoreactivity were detected between ductal epithelium of PCM and non-PCM. PMID: 24457076
- Reduced glycosylation of ICAM-2 significantly attenuated, but did not abolish, its ability to suppress metastatic properties of neuroblastoma cells. PMID: 23714211
- These findings suggested that the downregulated miR-125b expression was associated with proliferation and radioresistance mechanisms, probably through ICAM2 signalling. PMID: 23591197
- Immune surveillance occurs during the early intraepithelial stages of human pancreatic carcinogenesis and is mediated by expression of CXCL17 and ICAM2. PMID: 20955708
- Although ICAM-2 colocalizes with moesin and F-actin in microvilli of unstimulated endothelial cells, it is not involved in RhoA activation or cause stress fiber formation upon cross-linking. PMID: 12097408
- soluble DC-SIGN bound to gp120-Fc more than 100- and 50-fold better than ICAM-2-Fc and ICAM-3-Fc, respectively. Binding sites are described. PMID: 14970226
- The role of ICAM-2 has its recognition as potential therapeutic targets in human diseases. PMID: 15548573
- persistently elevated, serum levels of ICAM-2 throughout the various phases and types of Hemorrhagic fever with renal syndrome (HFRS) may be associated with the hyperfunctioning of the cellular immune response. PMID: 16987074
- pig and human ICAM-2 promoters exhibit many similarities PMID: 17059578
- The binding partner of DC-SIGN on endothelial cells is the glycan epitope Lewis(Y) (Le(Y)), expressed on ICAM-2. PMID: 18155766
- Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro. PMID: 18768213
- ICAM-2 mediates suppression of metastatic phenotype and the interaction of ICAM-2/alpha-actinin/actin represents the first complete membrane-linker protein-actin linkage to impact tumor cell motility in vitro and metastatic potential in an in vivo model. PMID: 18978946
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亞細(xì)胞定位：Membrane; Single-pass type I membrane protein. Cell projection, microvillus.
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蛋白家族：Immunoglobulin superfamily, ICAM family
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數(shù)據(jù)庫(kù)鏈接：
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