HSPBP1 Antibody
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中文名稱：HSPBP1兔多克隆抗體
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貨號：CSB-PA010845GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：1500019G21Rik antibody; FES1 antibody; Heat shock protein 70 binding protein antibody; Heat shock protein 70 interacting protein antibody; Heat shock protein binding protein 1 antibody; Heat shock protein-binding protein 1 antibody; Heat-shock 70-KD protein-binding protein 1 antibody; HPBP1_HUMAN antibody; Hsp 70 binding protein antibody; Hsp 70 interacting protein antibody; Hsp70 binding protein 1 antibody; Hsp70 binding protein 2 antibody; Hsp70 interacting protein 1 antibody; Hsp70 interacting protein 2 antibody; Hsp70-binding protein 1 antibody; Hsp70-binding protein 2 antibody; Hsp70-interacting protein 1 antibody; Hsp70-interacting protein 2 antibody; HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 antibody; HSPA-binding protein 1 antibody; HSPBP antibody; HspBP1 antibody; HspBP2 antibody; PP1845 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human HSPBP1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
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基因功能參考文獻：
- Findings indicate a critical role of HspBP1 in differential CHIP/Hsp70 activities in neuronal and glial cells and the greater neuronal vulnerability to misfolded proteins in neurodegenerative diseases. PMID: 28847953
- downregulation of Hsp70 and HspBP1 represents a unique feature of patients with preterm prelabor rupture of membranes PMID: 28497897
- our results clearly show that HspBP1 acts as an endogenous negative regulator of HIV-1 gene-expression and replication by suppressing NF-kappaB-mediated activation of viral transcription. PMID: 26538602
- Oxidative stress, inducing formation of disulfide bond, can affect stability and conformational mobility of human HspB1. PMID: 24898092
- BAG-1M and HspBP1 had differential impacts on the dynamic composition of steroid receptor folding complexes PMID: 24454860
- shown that HspBP1 binds Tag7 in the conditioned medium of tumor CSML0 cells, thereby preventing formation of the cytotoxic Tag7-Hsp70 complex PMID: 22037021
- High gene expression of HspBP1 is associated with leukemia. PMID: 20694586
- Results report cooperative interactions involving Hsp70, Hsp40, and TPR1 that enhance Hsp70-dependent folding of chemically denatured substrates. PMID: 14503850
- Detection of hsp70 may be used as the screening marker for diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer related lung cancer, and may supplement the diagnostic value of conventional cytology. PMID: 14761400
- BAG2 binds to the carboxyl terminus of Hsp70-interacting protein (CHIP) and provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP PMID: 16169850
- The results demonstrate that Hsp70 and HspBP1 are not coordinately regulated but provide evidence that an increase in the ratio of HspBP1 to Hsp70 correlates with apoptosis, in a similar way to reducing the amount of Hsp70. PMID: 16677834
- Stress-induced heat shock protein 70 (Hsp70) effectively protects cells against ultraviol ray-induced apoptosis in melanocytes bu penetrating mitchondrial and lysosomal membranes. PMID: 16950797
- Here, we report that upon the formation of huntingtin aggregates; endogenous cytosolic huntingtin, Hsc70/Hsp70 (heat shock protein and cognate protein of 70kDa) and syntaxin 1A become aggregate-centered. PMID: 17208201
- that HspBP1, by antagonizing the prosurvival activity of Hsp70, sensitizes tumor cells to cathepsin-mediated cell death. PMID: 17855353
- Association between endogenous LAP2alpha and Hsp70 in non-transfected cells was confirmed by co-immunoprecipitation. PMID: 18261988
- The two chaperones, HSP72 and HSPBP1, interact both physically and functionally, leading to the activation of th EGFR-ERK1/2 signalling pathway. PMID: 18986301
- Results indicate that low HspBP1 expression could be a marker of tumor aggressiveness. PMID: 18987994
- Our data suggest that HIP may prevent inclusion formation by facilitating the constitutive HSC70 refolding cycle and possibly by preventing aggregation. PMID: 19183265
- HspBP1 may play a role in tumor (dys)regulation of chaperone proteins PMID: 19659607
- The cochaperone HspBP1 binds to and inhibits Hsp70 activity. PMID: 9830037
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