HSF4 Antibody
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中文名稱：HSF4兔多克隆抗體
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貨號：CSB-PA010794GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：HSF4
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別名：Cataract; Marner antibody; CTM antibody; Heat shock factor protein 4 antibody; Heat shock transcription factor 4 antibody; hHSF4 antibody; HSF 4 antibody; HSF4 antibody; HSF4_HUMAN antibody; HSTF 4 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Human HSF4
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：DNA-binding protein that specifically binds heat shock promoter elements (HSE).; Transcriptional repressor.; Transcriptional activator.
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基因功能參考文獻：
- We have identified a novel mutation in HSF4 in a large British pedigree causing dominant congenital lamellar cataract PMID: 29243736
- High HSF4 expression is an independent indicator of poor overall survival and recurrence free survival in patients with primary colorectal cancer. PMID: 29131521
- In the cultured human lens epithelial cells, HSF4 could stabilize and retain p53 in the nucleus to activate its target genes such as fas cell surface death receptor (Fas) and Bcl-2-associated X apoptosis regulator (Bax). PMID: 28981088
- report on a novel homozygous HSF4 mutation (c.521T>C, p.Leu174Pro) in two sibs with congenital cataracts PMID: 26490182
- BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination. PMID: 26319152
- HSF4 may work as a switch between lens epithelial cell proliferation and secondary fiber cell differentiation, a process which mainly depends on p53. PMID: 25940838
- concluded that the new mutation of c.331C>T in HSF4 DNA may be responsible for the autosomal dominant congenital cataract in this family PMID: 25877371
- HSF4 p.Arg116His recreates the childhood lamellar cataract in mice suggesting that incomplete penetrance associated with early cataracts may not be an absence but a limitation of the detection of the phenotype PMID: 24975927
- This is the first report of the novel missense mutation, c.69 G-->T (p. K23N), in exon 3 of the HSF4 locus on 16q21-q22 associated with bilateral congenital cataracts in a Chinese family. PMID: 24637349
- the transcriptional activation of HSF4 is mediated by interactions between activator and repressor domains within the C-terminal end. PMID: 24045990
- HSF4 exerts its function on lens differentiation via positive regulation of DLAD expression. PMID: 23507146
- HSF4 and WRN CNVs might be involved in ARC pathogenesis in the Han Chinese. PMID: 23329665
- Presents the first evidence demonstrating that HSF4 plays a role in DNA damage repair and may contribute a better understanding of congenital cataract formation. PMID: 22587838
- we report the absence of mutations in all studied genes in four families with phenotypes associating cataract, mental retardation and microcephaly. PMID: 22103961
- HSF2 and HSF4 regulate transcription of HIF-1a and that a critical balance between these HSF is required to maintain HIF-a expression in a repressed state. PMID: 21258402
- two missense mutations that have been associated with age-related cataract did not or only slightly alter HSF4 activity, implying that other genetic and environmental factors affect the functions of these mutant proteins. PMID: 20670914
- Hsf4b could interact with and phosphorylated by MAP kinase P38. PMID: 20564821
- Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract. . We suggest that HSF4 is critical to lens development. PMID: 12089525
- This is the first report describing association of an autosomal recessive cataract with the HSF4 locus on 16q21-q22.1 and the first description of HSF4 splice variants PMID: 15277496
- HSF4 binds to alphaB-crystallin, Hsp70, and Hsp82 promoters and has a role in interacting with the canonical heat shock element of the alphaB-crystallin gene PMID: 15308659
- Findings confirm that mutations in HSF4 may result in both autosomal dominant and autosomal recessive congenital cataract, and highlight the locus heterogeneity in autosomal recessive congenital cataract. PMID: 15959809
- The results indicate that in the absence of Hsf1 and Hsf2, Hsf4b expression in cells leads to increased ability of Hsf4b to bind HSE during G1, leading to enhanced synthesis of inducible Hsp70. PMID: 16552721
- These results identified a novel missense mutation R74H in the transcription factor gene HSF4 in a Chinese cataract family and expand the spectrum of HSF4 mutations causing cataract. PMID: 16876512
- This result indicates that HSF4 mutations account for only a small fraction of age-related cataracts. PMID: 18941546
- we have shown the first nonsense mutation in HSF4 causing autosomal recessive cataracts in a large consanguineous family from Pakistan PMID: 19014451
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相關疾病：Cataract 5, multiple types (CTRCT5)
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亞細胞定位：Nucleus.
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蛋白家族：HSF family
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組織特異性：Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues.
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數據庫鏈接：
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