HPSE2 Antibody
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中文名稱(chēng)：HPSE2兔多克隆抗體
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貨號(hào)：CSB-PA010717GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：HPSE2
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別名：HPSE2 antibody; HPA2 antibody; Inactive heparanase-2 antibody; Hpa2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human HPSE2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).
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基因功能參考文獻(xiàn)：
- The results of this study the Heparanase 2 appeared overexpressed at different stages of Alzheimer disease. PMID: 28387673
- our results suggest that heparanase 2 functions as a tumor suppressor in bladder cancer PMID: 26968815
- we provide evidence that Hpa2 overexpression in head and neck cancer cells markedly reduces tumor growth PMID: 27013193
- The most common HPA genotypes among Saudis were HPA-1 a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA-4 a + b- (99%), HPA-5 a + b- (76.5%), HPA-6 a + b- (100%) and HPA-15 a + b + (50%). The prevalent allele among the HPA systems was (a), except in the HPA-15 system where the (b) allele was found in 52% of the subjects. PMID: 27019315
- Our findings identified these 2 genes as a novel breast cancer biomarker gene set, which may facilitate the diagnosis and treatment in breast cancer clinical therapies. PMID: 26084486
- HPSE2 mutations were found in one Urofacial syndrome family but not detected in patients with non-neurogenic neurogenic bladder and severe lower urinary tract dysfunction PMID: 25924634
- Heparanase 2 is more intensely expressed in the glandular tissue of cancer than in nonneoplastic endometrium; the HPSE2 expression in the stromal tissue is higher in the nonneoplastic controls compared with cancer mainly in the secretory endometrium. PMID: 25423319
- autonomic neural protein implicated in bladder emptying PMID: 25145936
- High expression of heparanase-2 is associated significantly with gastric tumor growth and differentiation PMID: 24139593
- Data indicate that the overexpression of HPSE1 and HPSE2 in the intervertebral degenerated discs suggests a role for these factors in mediating extracellular matrix remodeling in degenerative discs during disease development. PMID: 23370684
- HPSE2 c.631T>C (p.Y211H) is a novel benign SNP and c.1628A>T (p.N543I) is the disease-causing mutation in urofacial syndrome. PMID: 21332471
- A large region of marker homozygosity was observed at 10q24, consistent with known autosomal recessive inheritance, family consanguinity and previous genetic mapping in other families with Ochoa syndrome. PMID: 21450525
- Studies indicate that cathepsin L as the heparanase activating protease. PMID: 21308479
- These results indicate a regulatory effect of heparanase on TFPI and TFPI-2 in trophoblasts, suggesting a potential involvement of heparanase in early miscarriages. PMID: 20031192
- We now report evidence that Heparanse 2 (HPSE2) is the culprit gene for the syndrome. Mutations with a loss of function in the Heparanase 2 (HPSE2) gene PMID: 20560209
- Homozygous exonic deletions, nonsense mutations, and frameshift mutations in five further unrelated families confirmed HPSE2 as the causative gene for UFS PMID: 20560210
- Results demonstrated that the effectors from heparanase peptide-immunized mice could effectively lyse various tumor cells that were heparanase positive and HLA-A*0201 matched. PMID: 20182872
- Heparanase 2 is involved in neoplastic proliferation, but it was not exclusively associated with the malignant process. PMID: 19955924
- Heparanase may facilitate invasion and metastasis of gastric carcinoma cells. PMID: 15475937
- Study demonstrating that increased heparanase expression in prostate cancer tissues is due to promoter hypomethylation and up-regulation of transcription factor EGR1. PMID: 15709168
- Heparanase expression seems to be involved in the invasiveness and aggressiveness of head and neck squamous cell carcinomas. PMID: 15837740
- Heparanase expression is inversely correlated with survival of nasopharyngeal carcinoma (NPC) patients, indicating heparanase is a reliable prognostic factor, and further supports that heparanase is a valid target for the development of anti-cancer drugs. PMID: 16879396
- HPSE plays a role in extracellular matrix remodeling and in increasing heparin-binding growth factor release during embryo implantation. PMID: 17989358
- Data suggest that loss of modified heparan sulphate in the GBM is mediated by an increased heparanase presence and may play a role in the pathogenesis of diabetes-induced proteinuria. PMID: 18058084
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相關(guān)疾病：Urofacial syndrome 1 (UFS1)
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亞細(xì)胞定位：Secreted, extracellular space, extracellular matrix.
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蛋白家族：Glycosyl hydrolase 79 family
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組織特異性：Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and
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