HOXD3 Antibody

說明書

中文名稱：

HOXD3兔多克隆抗體
貨號：

CSB-PA005115
規格：

￥1090
圖片：
Western Blot analysis of HepG2 cells using HoxD3 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P31249
基因名：

HOXD3
別名：

Homeo box D3 antibody; Homeobox D3 antibody; Homeobox protein Hox D3 antibody; Homeobox protein Hox-4A antibody; Homeobox protein Hox-D3 antibody; Homeobox protein HoxD3 antibody; Homeodomain protein antibody; HOX 1D antibody; HOX 4 antibody; Hox 4.1 antibody; Hox 4A antibody; HOX D3 antibody; Hox-4.1 mouse homolog of antibody; HOX1D antibody; HOX4 antibody; Hox4.1 antibody; HOX4A antibody; HOXD 3 antibody; HOXD3 antibody; HXD3_HUMAN antibody; MGC10470 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human HoxD3.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
基因功能參考文獻：
1. The findings indicate that miR-203a inhibits hepatocellular carcinoma cell invasion, metastasis, and angiogenesis by negatively targeting HOXD3 and suppressing cell signaling through the VEGFR pathway. PMID: 29402992
2. EGR1 is a key player in the transcriptional control of miR-203a, and that miR-203a acts as an anti-oncogene to suppress HCC tumorigenesis by targeting HOXD3 through EGFR-related cell signaling pathways. PMID: 27244890
3. the HOXD3 gene promotes colorectal cancer cell growth and plays a pivotal role in the development and survival of malignant human colorectal cancer cells. PMID: 27499213
4. These results validate the association between promoter hypermethylation of ABHD9 and HOXD3 and prostate cancer recurrence PMID: 24718283
5. HOXD3 promoter hypermethylation is correlated with clinicopathologic features in prostate cancer. This correlation is more common in older, higher risk patients. PMID: 24847526
6. High expression of HOXD3 correlates with invasive breast cancer. PMID: 22935821
7. quantitative increase in promoter methylation levels of HOXD3 is associated with prostate cancer progression PMID: 21207416
8. HOXD3 methylation distinguishes low-grade prostate cancers from intermediate and high-grade ones. PMID: 20212450
9. transduction of antisense DNA into human melanoma cells results in decreased invasive and motile activities PMID: 12405287
10. Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo. PMID: 14610084
11. HoxD3 may provide a means to directly improve collagen deposition, angiogenesis and closure in poorly healing diabetic wounds. PMID: 14633614
12. HOXD3 may play an important role in regulating cerebral angiogenesis, and that gene transfer of HOXD3 may provide a novel and potent means to stimulate angiogenesis PMID: 15545924
13. The karyotype of our patient suggests another possible locus of the Duane syndrome, and the mapped genes around the deleted region, 1q42.13-43, contain possible candidate genes such as a homeobox gene. PMID: 17126050
14. Further validation of candidate genes on a separate cohort of low and high grade prostate cancers by quantitative MethyLight analysis has allowed us to confirm DNA hypermethylation of HOXD3 and BMP7... PMID: 19283074
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亞細胞定位：

Nucleus.
蛋白家族：

Antp homeobox family
數據庫鏈接：

HGNC: 5137

OMIM: 142980

KEGG: hsa:3232

STRING: 9606.ENSP00000249440

UniGene: Hs.93574

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