HOXB5 Antibody
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中文名稱：HOXB5兔多克隆抗體
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貨號：CSB-PA010665ESR1HU
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規格：￥440
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圖片：
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Western blot
All lanes: Homeobox protein Hox-B5 antibody at 8μg/ml
Lane 1: HepG2 whole cell lysate
Lane 2: Rat liver tissue
Lane 3: Rat lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 29 kDa
Observed band size: 29 kDa -
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA010665ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) HOXB5 Polyclonal antibody
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Uniprot No.：
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基因名：HOXB5
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別名：HGNC:5116 antibody; HHO.C10 antibody; Homeo box 2A antibody; Homeo box B5 antibody; Homeobox 2A antibody; Homeobox B5 antibody; Homeobox protein HHO.C10 antibody; Homeobox protein Hox B5 antibody; Homeobox protein Hox-2A antibody; Homeobox protein Hox-B5 antibody; Homeobox protein HoxB5 antibody; Homeobox protein Hu-1 antibody; Homeobox2A antibody; HomeoboxB5 antibody; HOX 2 antibody; Hox 2.1 antibody; HOX 2A antibody; HOX B5 antibody; HOX2 antibody; Hox2.1 antibody; Hox2.1, mouse, homolog of antibody; HOX2A antibody; HOXB 5 antibody; Hoxb5 antibody; HU 1 antibody; HU1 antibody; HXB5_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human, Rat
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免疫原：Recombinant Human Homeobox protein Hox-B5 protein (1-170AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
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基因功能參考文獻：
- for the first time we have shown that knockdown of HOXB5 significantly inhibited non-small cell lung cancer cell proliferation, invasion, metastasis, and epithelial-mesenchymal transformation, partly through the Wnt/beta-catenin signaling pathway PMID: 28337958
- Taken together, our results for the first time suggested that miR-455-3p was downregulated in NSCLC and was correlated with the poor prognosis of NSCLC patients. Also, miR-455-3p functions as tumor suppressor by directly targeting HOXB5 in NSCLC progression and may be used as a potential target for NSCLC treatment. PMID: 29170127
- HOXB5 acts as a positive modulator by promoting cell proliferative response and invasiveness in ER-positive breast cancer. PMID: 25999793
- HOXB5 may be an important regulator of the Wnt/beta-catenin signalling pathway, thereby contributing to gastric cancer progression and metastasis. PMID: 26467157
- Roles of Hoxb5 in the development of vagal and trunk neural crest cells. PMID: 25703667
- Overexpression of HoxB5 enhances blood vessel perfusion in vivo by up-regulation of MCP-1 and IL-6 as well as in enhanced leucocyte infiltration and blood vessel remodelling. PMID: 24189625
- HOXB5 and HOXB8 are frequently expressed in ovarian serous carcinoma, with anatomic site-related differences for cytoplasmic staining. HOXB5 may be affected by chemotherapy in effusions. PMID: 23438671
- The findings for HOXB5 and PHOX2B provide supportive evidence that genes regulating ENCC proliferation, migration and differentiation could be risk factors for Hirschsprung's disease PMID: 22648184
- A miRNA 7-binding single nucleotide polymorphism (1010A/G) located within 3'-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer. PMID: 22768238
- HOXB5, HOXB6, and HOXB7 are activated in Barrett esophagus, and the midcluster HOXB gene signature in BE most resembled the colon rather than other GI epithelia. PMID: 22603795
- Single nucleotide polymorphism in HOXB5 gene is associated with childhood obesity. PMID: 22484627
- results support that expression of HOX genes is associated with oral squamous cell carcinoma; over 90% of OSCC samples presented HOXB5 expression versus 60% of non-tumor tissues, it can be suggested that HOXB5 may be related to the malignant phenotypes. PMID: 21552713
- Data show that human HOXB5 binds to the promoter region 5' upstream of the binding site of NKX2-1 and regulates RET expression. PMID: 21677782
- HoxB5 is necessary and sufficient to activate the cell-intrinsic events that regulate the differentiation of angioblasts and mature endothelial cells from their mesoderm-derived precursors PMID: 12897140
- The expression pattern of HOXB5 correlated with the migration and differentiation of neural crest cells. PMID: 12950074
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亞細胞定位：Nucleus.
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蛋白家族：Antp homeobox family
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組織特異性：Spinal cord.
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數據庫鏈接：
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