HOXA7 Antibody

說明書

中文名稱：

HOXA7兔多克隆抗體
貨號：

CSB-PA002957
規格：

￥1090
圖片：
Western Blot analysis of Jurkat cells using Hox-A7 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P31268
基因名：

HOXA7
別名：

ANTP antibody; Antp, Drosophila, homolog of antibody; Homeobox 1A antibody; Homeobox A7 antibody; Homeobox protein Hox 1.1 antibody; Homeobox protein Hox A7 antibody; Homeobox protein Hox-1A antibody; Homeobox protein Hox-A7 antibody; HOX1 antibody; HOX1.1 antibody; HOX1.1, mouse, homolog of antibody; Hox1A antibody; HOXA7 antibody; HXA7_HUMAN antibody; OTTHUMP00000024835 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human Hox-A7.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
基因功能參考文獻：
1. Silencing of HOTAIR and HOXA7 could effectively inhibit tumor growth and increase chemosensitivity of ovarian tumors in nude mice. PMID: 29455183
2. data suggest that HOXA7 could serve as a diagnostic marker for OSCC or a treatment target PMID: 28529281
3. Results showed that HOXA7 was highly expressed in liver cancer cells which related with poorer prognosis. Its overexpression significantly promoted invasion and metastasis of liver cancer cells by activating Snail expression. PMID: 27600149
4. The homeodomain and N- and C-termini are critical to transcriptional activation by Hoxa1 protein. The N-terminus also modulates interaction with Pbx1a protein during DNA-binding. PMID: 20336696
5. HOXA7 might be a new gene candidate that influences the maturation of acute myeloid leukemia. PMID: 26828989
6. HOXA7 promotes cell proliferation, and these changes were mediated by cyclin E1/CDK2 PMID: 25501982
7. variants in the HOXA7 and HOXA9 genes are not common in Chinese women with Mullerian duct abnormalities PMID: 25246116
8. This finding contributes to our understanding of the role HOXA7 plays in regulating the proliferation of ER-positive cancer cells. PMID: 24099775
9. Hoxa7, Hoxa9 and Hox cofactor Meis1 were identified as AP-2alpha target genes, which are involved in myeloid leukemogenesis. PMID: 23660297
10. Data show that up-regulation of the HOXA7, HOXA9, HOXA11, and PBX3 resulting from the down-regulation of miR-181 family members probably contribute to the poor prognosis of patients with nonfavorable cytogenetically abnormal AML (CA-AML). PMID: 22251480
11. found evidence for association of bone geometry variation with an SNP in ENPP1, a gene in the mineralization pathway. The alteration of a binding site of the deregulator of extracellular matrix HOXA7 warrants further investigation PMID: 19888898
12. Taken together, these results support the notion that down-regulation of PCGF2 is sufficient to induce granulocytic differentiation of HL-60 cells via de-repression of HOXA7 gene expression. PMID: 22085718
13. Several targets of MLL fusions, MEIS1, HOXA7, HOXA9, and HOXA10 are functionally related and have been implicated in leukemias. Each of the four genes was knocked down separately in the precursor B-cell leukemic line RS4;11 expressing MLL-AF4. PMID: 21518888
14. HOXA7, PIXT1 and PRRX1 homeobox genes have different patterns of expression in oral squamous cell carcinomas depending on its histological features. PMID: 21323949
15. A novel mechanistic role for HOXA7 in modulating granulosa cell proliferation via upregulation of EGFR. PMID: 20540809
16. B-lineage development can proceed in t(4;11) leukemic blasts in the absence of HOX-A gene expression. PMID: 14562113
17. Hox A7-sustained expression disturbs the regulation of cell adhesive and migratory capacities on fibronectin during early differentiation. PMID: 14704364
18. Study reveals the preferential expression of HOXA7 by germinal vesicle (GV) oocytes. PMID: 16597639
19. HOXA7 staining of tumor cell nuclei is correlated significantly with improved disease-specific survival, which is suggestive of the biological and potentially clinical importance of subcellular HOXA7 localization. PMID: 17959889
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亞細胞定位：

Nucleus.
蛋白家族：

Antp homeobox family
數據庫鏈接：

HGNC: 5108

OMIM: 142950

KEGG: hsa:3204

STRING: 9606.ENSP00000242159

UniGene: Hs.610216

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