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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Sequence-specific transcription factor. Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior. Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments. Activates transcription in the presence of PBX1A and PKNOX1.
基因功能參考文獻:
We speculate that HOXA1 may be the direct target of miR181b5p or miR181d5p in LUSC, and HOXA1 may serve a significant role in nonsmall cell lung cancer (NSCLC) by regulating various pathways, particularly the p53 signaling pathway. PMID: 29658571
Study revealed the existence of negative correlation between the expression of miR577 and HOXA1 in hepatocellular carcinoma (HCC) specimens. HOXA1 expression is under the direct regulation of miR577 which is able to bind to its 3'UTR. PMID: 29693150
HOTTIP cooperates with CTCF to coordinate HOXA gene expression. PMID: 29698677
that miR-433 was frequently downregulated in colon cancer tissues and cell lines. Overexpression of miR-433 significantly inhibited the proliferation and invasion of colon cancer. We also newly identified HOXA1 as a direct target of miR-433. The effects of miR-433 on colon cancer cells were mediated via HOXA1. PMID: 29137689
we found that KDM3B exhibits potential tumor-suppressive activity and transcriptionally modulates HOXA1 expression via RARE in AML. PMID: 28540746
miR-30c could suppress giant cell tumor of bone cell proliferation and progression via HOXA1, which might provide a new target for giant cell tumor of bone diagnosis and therapy PMID: 29164581
UBE2C and HOXA1 RNA and protein are differentially expressed in conventional and Spitz nevi and melanoma. PMID: 28657121
Study identified HOXA1 as a direct target of miR-30e. Its expression is down-regulated by miR-30e played leading to suppressed lung cancer cell growth. PMID: 27992364
HOXA1-mediated activation of NF-kappaB is non-transcriptional and the RBCK1 and TRAF2 influences on NF-kappaB are epistatic to HOXA1 PMID: 27382069
Overexpression of the HOXA1 expression is associated with increased transformation of myelodysplastic syndrome into acute myeloid leukemia. PMID: 26812882
Data indicated that HOXA1 and CCND1 mRNA and protein expression were higher in gastric cancer (GC) tissues, that a significant correlation was found between their expression, and they both may serve as a novel prognostic biomarker for GC. PMID: 26791264
MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells. PMID: 26417931
In a Middle Eastern population, HOXA1 is not likely a common cause of non-syndromic deafness. PMID: 24878468
our findings suggest that HOXA1 is involved in the regulation of prostate cancer progression, including cell growth, migration, invasion and metastasis PMID: 26135141
Studied HOTAIR in chemoresistance of SCLC and possible molecular mechanism. Knockdown of HOTAIR was carried out in SCLC multidrug-resistant cell lines; found depletion of HOTAIR reduced HOXA1 methylation by decreasing DNMT1 & DNMT3b expression. PMID: 26707824
YAP regulates the expression of HOXA1 and HOXC13 in human keratinocytes. PMID: 25691658
Analysis indicates that the genes BIRC5, HOXA1 and RARB are critical targets that play an important regulatory role in cervical cancer pathogenesis. PMID: 25069511
ACK1 interacts with KDM3A to regulate the mammary tumor oncogene HOXA1. PMID: 25148682
MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells. PMID: 24312487
The results demonstrated that miR-181c transcription is suppressed and HOXA1 expression is enhanced in hepatitis C virus-infected hepatocytes. PMID: 24789793
HOXA1-mediated SCLC chemoresistance is under the regulation of miR-100. HOXA1 may be a prognostic predictor and potential therapeutic target in human SCLC PMID: 24559685
validation data and mechanistic insights suggest that patients whose primary tumors express HOXA1 are among a high-risk metastasis subgroup that should be considered for anti-TGFbeta therapy in adjuvant settings PMID: 23435427
Data indicate that MiR-10a has a role in megakaryocyte differentiation of stem cells via HOXA1 transcription factor targeting. PMID: 23321646
The findings in this patient raise the possibility that PTPRN2 may be active during early development of the human brainstem and that its overexpression may cause bilateral Duane retraction syndrome as occurs in patients with homozygous HOXA1 mutations. PMID: 22950449
Overexpression of HOXA1 is associated with hepatocellular carcinoma. PMID: 22864671
Loss of HOXA1 is associated with pancreatic cancer. PMID: 22407312
study demonstrates KDM3A is overexpressed in various types of cancer and directly activates transcription of HOXA1 through demethylation of histone H3K9 by binding to its promoter region PMID: 22020899
HOXA1 may contribute to oral carcinogenesis by increasing tumor cell proliferation, and suggest that HOXA1 expression might be helpful as a prognostic marker for patients with oral squamous cell carcinoma. PMID: 22498108
the importance of the Hox-Pbx interaction for the oncogenic activity of Hoxa1 PMID: 21957483
HOXA1 A218G and HOXB1 nINS/INS variants may not contribute significantly to autism spectrum disorders risk PMID: 21980499
the combination of miR-377 and miR-217 help regulate HO-1 protein expression in the presence of hemin PMID: 21106538
HOXA1 mutations are not a common cause of sporadic Mobius syndrome in the general population PMID: 20227628
It is unlikely that HoxA1 plays a significant role in the genetic predisposition to autism. PMID: 11840501
No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network PMID: 12210285
hoxa1 protein plays a role in the development of infantile autism PMID: 12349873
HOXA1 is a human mammary epithelial oncogene with aggressive in vivo tumor formation PMID: 12482855
The HOXA1 A218G polymorphism explains approximately 5% of the variance in the head circumference of autistic patients and represents to our knowledge the first known gene variant providing sizable contributions to cranial morphology. PMID: 14960295
Mutations in HOXA1 resulting in abnormalities, deafness, facial weakness, hypoventilation, vascular malformations of the internal carotid arteries and cardiac outflow tract, mental retardation and autism spectrum disorder were identified. PMID: 16155570
HOXA1 protein with polyhistidine tract expansions misfold, aggregate, and have a toxic effect on cell. PMID: 16168961
HOXA1 is a downstream effector of E-cadherin-directed signaling required for anchorage-independent proliferation of mammary carcinoma cells. PMID: 16373333
The HOXA1-related syndrome phenotype is variable; HOXA1 mutations are a rare cause of isolated Duane anomaly. PMID: 16528738
Study reveals the preferential expression of HOXA1 by metaphase II oocytes. PMID: 16597639
Expanded polyhistidine repeats in HOXA1 enhance aggregation and cell death, resulting in impaired neuronal differentiation and cooperative binding with PBX1. PMID: 17131398
Variation not associated with autism in an Indian population. PMID: 17167333
HOXA1 A218G alleles significantly influence head growth rates, but not final head size, in normal human development. PMID: 17171652
Modulation of the p44/42 MAP kinase pathway is one mechanism by which HOXA1 mediates oncogenic transformation of the human mammary epithelial cell. PMID: 17213808
This report extends the Bosley-Salih-Alorainy syndrome phenotype and documents the clinical variability resulting from identical HOXA1 mutations within an isolated ethnic population PMID: 17875913
Results identified HOXA1 loci showing significant differential DNA methylation levels between tumor and non-tumor lung and highly significant hypermethylation in adenocarcinoma. PMID: 17967182
HOXA1 partially mediates oncogenic transformation of the immortalized human mammary epithelial cell through modulation of the STAT3 and STAT5B pathways. PMID: 18276758
study describes nine previously unreported individuals from six families who have homozygous mutations of HOXA1 and either the Bosley-Salih-Alorainy syndrome (BSAS) or the Athabascan brainstem dysgenesis syndrome (ABDS) PMID: 18412118