HOPX Antibody

中文名稱：

HOPX兔多克隆抗體
貨號：

CSB-PA859411LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA859411LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) HOPX Polyclonal antibody
Uniprot No.：

Q9BPY8
基因名：

HOPX
別名：

CAMEO antibody; heart odd homeobox 1 protein antibody; HOD antibody; Homeodomain-only protein antibody; HOP antibody; HOP homeobox antibody; HOP_HUMAN antibody; HOPX antibody; LAGY antibody; Lung cancer-associated Y protein antibody; NECC1 antibody; Not expressed in choriocarcinoma clone 1 antibody; Not expressed in choriocarcinoma protein 1 antibody; OB1 antibody; odd homeobox 1 protein antibody; Odd homeobox protein 1 antibody; OTTHUMP00000158970 antibody; SMAP31 antibody; TOTO antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Homeodomain-only protein (1-73AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，HOPX Antibody (CSB-PA859411LA01HU)，的標記方式是Non-conjugated。對于HOPX Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA859411LB01HU	HOPX Antibody, HRP conjugated	ELISA
FITC	CSB-PA859411LC01HU	HOPX Antibody, FITC conjugated
Biotin	CSB-PA859411LD01HU	HOPX Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
基因功能參考文獻：
1. Data suggest that HOP homeobox HOPX (HOPX) acts as a tumour suppressor via the epigenetic regulation of snail family transcription factors (SNAIL) transcription and a prognostic biomarker for nasopharyngeal carcinoma (NPC) metastasis and therapeutic target for NPC treatment. PMID: 28146149
2. HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis PMID: 27934959
3. The association between the MEEVD C-terminal peptide from the heat shock protein 90 (Hsp90) and tetratricopeptide repeat A (TPR2A) domain of the heat shock organizing protein (Hop) is a useful prototype to study the fundamental molecular details about the Hop-Hsp90 interaction. Observed are conformational changes of the peptide and the protein receptor induced by binding. The binding free energy is 8.4 kcal/mol. PMID: 28723223
4. HOPX is functionally regulated by SCL in hematoendothelial differentiation of mesoderm progenitor cells. PMID: 28813672
5. HOPX is a distinctive homeobox gene with characteristic clinical and biological implications and its expression is a powerful predictor of prognosis in AML patients. PMID: 28341738
6. HOPX has a role in the pathogenesis of skin cancers and skin diseases. PMID: 27017330
7. these data indicate that the disruption of the PrP(C)-HOP complex could be a potential therapeutic target for modulating the migratory and invasive cellular properties that lead to metastatic Colorectal cancer (CRC). PMID: 27112151
8. HOPX promoter methylation is not only frequent and cancer-specific but also associated with aggressive phenotype in breast cancer. PMID: 27756570
9. Computational results identified HOPX gene as a new potential driver for ovarian carcinogenesis. PMID: 27287041
10. The results suggest that HOPX may contribute to pathogenesis or manifestation of hypertrophic cardiomyopathy as a modifier gene. PMID: 25036325
11. Data show that binding of heat shock proteins Hsp70 and Hsp90 requires prior binding of Hop protein to Hsp90. PMID: 26286954
12. HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer. PMID: 25345926
13. GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype. PMID: 23707782
14. HOPX-beta promoter methylation is a frequent and cancer-specific event in CRC progression. PMID: 22904674
15. Knockdown of Hop caused a decrease in the level of RhoC GTPase, and significantly inhibited pseudopodia formation in Hs578T cells. Our data suggest that Hop regulates directional cell migration by multiple unknown mechanisms. PMID: 23036489
16. HOPX/Hopx expression is reduced in multiple examples of human and murine cardiac hypertrophy and failure. PMID: 21382376
17. results identify distinct functions for the Hop cochaperone, revealing an asymmetric mechanism for Hsp90 regulation and client loading PMID: 21700222
18. HOP is a novel modulator of late terminal differentiation in keratinocytes PMID: 21256618
19. Hopx regulates the expression of genes involved in regulation of apoptosis and survival and makes them refractory to Fas-induced apoptosis. PMID: 21061432
20. HOPX-beta promoter methylation is a frequent and cancer-specific event in gastric cancer PMID: 20228841
21. HOPX is modulated by cell differentiation in human keratinocytes and this might contribute to homeostasis of keratinocytes by controlling differentiation-dependent genes. PMID: 20226564
22. Loss of NECC1 expression is involved in malignant conversion of placental trophoblasts. PMID: 12573257
23. Gene mapping locates LAGY on chromosome 4q11-13.1. In 72 primary lung tumors, this gene was significantly down-regulated compared to 9 normal lung tissue samples. PMID: 12759545
24. One role of Hop is to modify the expression of cardiac-specific genes and thereby finely regulate heart development. PMID: 14522464
25. Decrease in homeodomain-only protein is associated with hypopharyngeal carcinoma PMID: 15213722
26. SMAP31 expression is elevated in 4 of 6 papillary thyroid tumor samples compared to 4 normal thyroid controls. PMID: 15307938
27. loss of NECC1 expression is involved in malignant conversion of placental trophoblasts PMID: 15457851
28. Our results demonstrate that the homeodomain fold has been co-opted during evolution for functions other than sequence-specific DNA binding and suggest that HOP functions as an adaptor protein to mediate transcriptional repression. PMID: 16939210
29. The data indicate that signaling induced by hop/STI-1 depends on endocytosis PMID: 17498662
30. Gradual induction of HOP/NECC1 in response to differentiation stimuli may result in the decision to differentiate into a particular type of trophoblastic cell lineage and result in non-lethal defects PMID: 17576768
31. HOP is a putative tumor suppressor gene that harbors tumor inhibitory activity. PMID: 18234960
32. HOP may work as a tumor suppressor in a subset of glioblastomas; HOP function thus appears to be critical in the adult brain in a region of continued plasticity, and its deregulation may contribute to disease PMID: 18507846
33. transcriptional silencing of HOPX results from hypermethylation of the HOPpromoter, which leads to human uterine endometrial cancers (HEC) development. PMID: 19173292
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亞細胞定位：

Nucleus. Cytoplasm.
組織特異性：

Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma an
數據庫鏈接：

HGNC: 24961

OMIM: 607275

KEGG: hsa:84525

STRING: 9606.ENSP00000450527

UniGene: Hs.619396

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