HMGCS2 Antibody

說明書

中文名稱：

HMGCS2兔多克隆抗體
貨號：

CSB-PA045049
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA045049(HMGCS2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA045049(HMGCS2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA045049(HMGCS2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

P54868
基因名：

HMGCS2
別名：

3 hydroxy 3 methylglutaryl Coenzyme A synthase 2 (mitochondrial) antibody; 3 hydroxy 3 methylglutaryl Coenzyme A synthase 2 antibody; 3 hydroxy 3 methylglutaryl coenzyme A synthase antibody; 3-hydroxy-3-methylglutaryl coenzyme A synthase antibody; HMCS2_HUMAN antibody; HMG CoA synthase antibody; HMG-CoA synthase antibody; HMGCS 2 antibody; HMGCS2 antibody; Hydroxymethylglutaryl CoA synthase antibody; Hydroxymethylglutaryl CoA synthase mitochondrial antibody; Hydroxymethylglutaryl-CoA synthase antibody; mitochondrial antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human HMGCS2
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:10000
WB	1:500-1:2000
IHC	1:100-1:300

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
基因功能參考文獻(xiàn)：
1. several nutrients as well as specific nutritional related hormonal conditions are able to affect significantly HMGCS2 gene expression. PMID: 28888048
2. miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma PMID: 28867541
3. this studies demonstrate that HMGCS2 functions as a transcriptional factor that binds to peroxisome proliferator-activated receptor alpha (PPARalpha), resulting in Src expression and activation in a metabolically independent manner PMID: 27816970
4. HMGCS2 shares with ketone bodies common features in autophagic clearance of APP, suggesting that ketone bodies play an important role in HMGCS2 regulation of the autophagy. PMID: 28320515
5. High expression of either HSD17B2 or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy. PMID: 25929810
6. FABP7 and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast PMID: 25389781
7. In Fe-S cluster-deficient muscles, results show a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21). PMID: 23943793
8. Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression PMID: 21502324
9. Ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2. PMID: 16940161
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相關(guān)疾病：

3-hydroxy-3-methylglutaryl-CoA synthase-2 deficiency (HMGCS2D)
亞細(xì)胞定位：

Mitochondrion.
蛋白家族：

HMG-CoA synthase family
組織特異性：

Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle. Not detected in brain.; [Isoform 3]: Highest expression detected in heart and skeleta
數(shù)據(jù)庫鏈接：

HGNC: 5008

OMIM: 600234

KEGG: hsa:3158

STRING: 9606.ENSP00000358414

UniGene: Hs.59889

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