HINT2 Antibody
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中文名稱：HINT2兔多克隆抗體
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貨號：CSB-PA239614
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA239614(HINT2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：HINT2
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別名：1190005L05Rik antibody; HINT-2 antibody; HINT-3 antibody; HINT2 antibody; HINT2_HUMAN antibody; histidine triad nucleotide binding protein 2 antibody; Histidine triad nucleotide-binding protein 2 antibody; HIT-17 antibody; HIT-17kDa antibody; mitochondrial antibody; PKCI-1-related HIT protein antibody; Protein kinase C inhibitor 2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthetic peptide of Human HINT2
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 IHC 1:10-1:50 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro. May be involved in steroid biosynthesis. May play a role in apoptosis.
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基因功能參考文獻(xiàn)：
- Authors deduced that HINT2 triggers apoptosis in pancreatic cancer cells by regulating mitochondrial Ca(2+) influx through the mitochondrial calcium uniporter (MCU). Authors found that HINT2 can sensitize BxPC-3 and L3.6pl cells to gemcitabine-induced apoptosis and that gemcitabine up-regulates HINT2 expression. PMID: 28947137
- HINT2 downregulation depended on hypoxia inducible factor (HIF)-2alpha-mediated transcriptional activation of zinc finger E-box-binding homeobox 1 (ZEB1). These results suggest that HINT2 downregulation promotes HIF-2alpha expression, which induces EMT and enhances CRC cell migration and invasion. PMID: 28088787
- Low HINT2 expression is associated with low response to therapy in endometrial cancer. PMID: 23682076
- X-ray crystal structure of human HINT2 with and without bound AMP. PMID: 23659632
- Hint2 is required for an optimal steroidogenic response, possibly because of a particular signalling function exerted within the mitochondria. PMID: 18653718
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亞細(xì)胞定位：Mitochondrion.
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蛋白家族：HINT family
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組織特異性：High expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.
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數(shù)據(jù)庫鏈接：
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