HIKESHI Antibody
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中文名稱：HIKESHI兔多克隆抗體
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貨號：CSB-PA706632HA01HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA706632HA01HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA706632HA01HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) HIKESHI Polyclonal antibody
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Uniprot No.：
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基因名：HIKESHI
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別名：C11orf73 antibody; Chromosome 11 open reading frame 73 antibody; CK073_HUMAN antibody; FLJ43020 antibody; Hikeshi antibody; HSPC138 antibody; HSPC179 antibody; L7RN6 antibody; Lethal Chr 7 Rinchik 6 antibody; OPI10 antibody; Protein Hikeshi antibody; Uncharacterized protein C11orf73 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Protein Hikeshi protein (1-197AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，HIKESHI Antibody (CSB-PA706632HA01HU)，的標記方式是Non-conjugated。對于HIKESHI Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
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基因功能參考文獻：
- Our results suggest that HIKESHI is a marker of cancer progression and that the combination of HIKESHI inhibition and hyperthermia is a therapeutic tool for refractory gastric cancer PMID: 28731175
- Depletion of Hikeshi renders HeLa cells proteotoxic stress-sensitive through the abrogation of the nuclear function of HSP70s required for HSF1 regulation. PMID: 28980748
- A novel homozygous variant in HIKESHI was identified in a patient with hypomyelinating leukoencephalopathy with periventricular cysts and vermian atrophy. Modified interactions inside Hikeshi's hydrophobic pockets induce mutant protein instability. PMID: 28000699
- Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene.P.V54L mutation in Hikeshi is associated with absence of nuclear HSP70 during heat shock stress. PMID: 26545878
- The crystal structure of Hikeshi explains how Hikeshi participates in the regulation of nuclear import through the recognition of FG-Nups and which part of Hikeshi affects its binding to Hsp70. PMID: 25760597
- identify a nuclear import pathway that operates during heat shock stress and is mediated by an evolutionarily conserved protein, Hikeshi (coded by the C11orf73 gene) binds to FG-Nups and translocates through nuclear pores on its own, showing characteristic features of nuclear transport carriers. PMID: 22541429
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相關疾病：Leukodystrophy, hypomyelinating, 13 (HLD13)
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亞細胞定位：Cytoplasm. Cytoplasm, cytosol. Nucleus.
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蛋白家族：OPI10 family
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數據庫鏈接：
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