HEY2 Antibody
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中文名稱(chēng)：HEY2兔多克隆抗體
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貨號(hào)：CSB-PA993153
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規(guī)格：￥2024
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圖片：
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Western blot analysis of extracts from K562 cells, using HEY2 antibody.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱(chēng)：Rabbit anti-Homo sapiens (Human) HEY2 Polyclonal antibody
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Uniprot No.：
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基因名：HEY2
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Synthesized peptide derived from internal of Human HEY2.
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免疫原種屬：Homo sapiens (Human)
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克隆類(lèi)型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
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基因功能參考文獻(xiàn)：
- The findings identify HEY2 as a novel component of the NKX2-5 cardiac transcriptional network. PMID: 29636455
- HEY2 as a promising biomarker for unfavorable outcomes and a novel therapeutic target for the clinical management of HCC PMID: 27191260
- Genetic variation of HEY2 is associated with Brugada syndrome through alteration of ion channel expression in the cardiac ventricular wall. PMID: 28637782
- Individuals with HEY2 duplications should be screened for congenital heart defects. PMID: 25832314
- HEY2 CC genotype may be a favorable prognostic marker for BrS, protectively acting to prevent ventricular fibrillation presumably by regulating the repolarization current. PMID: 26729854
- Data indicate that culture abrogated differential gene expression in part due to gradual loss of canonical Notch activity and HEY2 expression. PMID: 24108462
- Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death PMID: 23872634
- Hey2 and COUP-TFII have an important role in arteriovenous differentiation of human endothelial cells. PMID: 23744056
- Report down-regulation of Notch signaling components NOTCH3 and HEY2 in abdominal aortic aneurysms. PMID: 22310065
- Through activating the Dll4-Notch-Hey2 signaling pathway, HGF indirectly promotes the proliferation and migration ability of cells, so that offspring artery branches are formed. PMID: 21362320
- To clarify the role of HEY2 in human CHD and AGS, we screened by direct sequencing 23 children with CHD and 38 patients diagnosed with AGS. Mutation of HEY2 is not a major contributing factor. PMID: 15389319
- HERP1 may play a role in promoting the phenotypic modulation of vascular smooth muscle cells during vascular injury and atherosclerotic process by interfering with SRF binding to CArG-box PMID: 16151017
- CHF1/Hey2 may affect smooth-muscle cell phenotype through an important transcriptional mechanism PMID: 16293227
- This result suggests a possible role of HEY2 in the regulation of ventricular septation in humans. PMID: 16329098
- The absence of mutations in NOTCH2 and Hey2 its downstream target in the heart does not exclude the possibility that other genes in this pathway might be implicated in the diverse phenotypes observed in Alagille syndrome PMID: 18266235
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亞細(xì)胞定位：Nucleus.
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蛋白家族：HEY family
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數(shù)據(jù)庫(kù)鏈接：
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