HDAC11 Antibody
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中文名稱：HDAC11兔多克隆抗體
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貨號：CSB-PA010237ESR1HU
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規(guī)格：￥440
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圖片：
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Western blot
All lanes: HDAC11 antibody at 2μg/ml + Mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 40, 34 kDa
Observed band size: 40 kDa -
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA010237ESR1HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) HDAC11 Polyclonal antibody
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Uniprot No.：
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基因名：HDAC11
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別名：FLJ22237 antibody; HD 11 antibody; HD11 antibody; HDA11_HUMAN antibody; HDAC 11 antibody; HDAC11 antibody; Histone deacetylase 11 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human, Mouse
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免疫原：Recombinant Human Histone deacetylase 11 protein (1-347AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:200-1:1000 IHC 1:20-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
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基因功能參考文獻(xiàn)：
- The results indicated that HDAC11 was significantly expressed in human and mouse diabetic heart failure (DHF) hearts. PMID: 29655790
- Mycobacterium tuberculosis infection disturbs the HDAC6/HDAC11 levels to induce IL-10 expression in macrophages. PMID: 29523311
- HDAC11 was initially identified as a negative regulator of the well-known anti-inflammatory cytokine IL-10. Hence, antagonizing HDAC11 activity may have anti-tumor potential, whereas activating HDAC11 may be useful to treat chronic inflammation or autoimmunity. PMID: 29222071
- Results showed that the high levels of HDAC11 and lower levels of p53 were detected in pituitary tumor cells. A negative correlation was detected between the data of HDAC11 and p53. PMID: 28782861
- Our study identified a group of cell cycle-promoting genes regulated by HDAC11. PMID: 28252645
- High HDAC11 expression is associated with neoplasms. PMID: 23024001
- Data indicate a pronounced deregulation of HDAC genes HDAC9 and HDAC11 in patients with Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF). PMID: 21806350
- These results demonstrate for the first time that HDAC11 plays an essential role in regulating OX40L expression. PMID: 21239696
- HDAC11 associates with replication origins inhibits Cdt1-induced re-replication and suppresses MCM loading. PMID: 20980834
- We found a reduction of HDAC 11 mRNA and increased HDAC 2 levels in amyotrophic lateral sclerosis brain and spinal cord compared with controls. PMID: 20467334
- cloning and functional characterization PMID: 11948178
- Fluorescence in situ hybridization analysis localized HDAC11 gene to chromosome 3p25, a region characterized by frequent gains and losses of chromosomal material in a number of various types of cancer. PMID: 16142391
- the absence of tumour-specific somatic events in WNT7A and HDAC11 suggests that these genes are unlikely to have a classical tumour suppressor gene role in sporadic malignant pancreatic endocrine tumours PMID: 17201809
- HDAC11 negatively regulated expression of the gene encoding interleukin 10 in antigen-presenting cells. PMID: 19011628
- Cdt1 undergoes acetylation and is reversibly deacetylated by HDAC11 PMID: 19276081
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亞細(xì)胞定位：Nucleus. Note=Predominantly nuclear.
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蛋白家族：Histone deacetylase family
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組織特異性：Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
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數(shù)據(jù)庫鏈接：
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