HDAC10 Antibody
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中文名稱：HDAC10兔多克隆抗體
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貨號(hào)：CSB-PA249520
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規(guī)格：￥2024
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圖片：
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Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using HDAC10 antibody. -
Western blot analysis of extracts from COS7 cells, using HDAC10 antibody. -
Western blot analysis of extracts from JK cells (Lane 2) and cos-7 cells (Lane 3), using HDAC10 antiobdy. The lane on the left is treated with synthesized peptide.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) HDAC10 Polyclonal antibody
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Uniprot No.：
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基因名：HDAC10
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from Human HDAC10.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair.
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基因功能參考文獻(xiàn)：
- HDAC10 structure and molecular function as a polyamine deacetylase has been reported. PMID: 28516954
- this study demonstrated that HDAC10 localizes and functions in the cytoplasm of lung cancer cells, thereby underscoring its potential role in the diagnosis and treatment of lung cancer PMID: 27449083
- HDAC10 regulates cyclin A2 expression by deacetylating histones near the let-7 promoter. PMID: 26240284
- study identifies an HDAC10-mediated regulatory mechanism controlling the DNA mismatch repair function of MSH2. PMID: 26221039
- Suggest HDAC10 expression as a prognostic marker for gastric cancer. PMID: 25337229
- this study is describing HDAC10 as a promoter of autophagy-mediated survival in neuroblastoma cells and identifying this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival. PMID: 24145760
- HDAC10 suppresses expression of matrix metalloproteinase (MMP) 2 and 9 genes, which are known to be critical for cancer cell invasion and metastasis PMID: 23897811
- results demonstrate that HDAC10 protects cancer cells from cytotoxic agents by mediating autophagy and identify this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival PMID: 23801752
- Histone deacetylases 9 and 10 are required for homologous recombination. PMID: 21247901
- HDAC10 is involved in transcriptional downregulation of TXNIP, leading to altered reactive oxygen species signaling in human gastric cancer cells. PMID: 20680488
- Results not only show that HDAC10 regulates melanogenesis but also demonstrate that the transcriptional activities of Pax3 and KAP1 are intimately linked to their acetylation status. PMID: 20032463
- another histone deacetylase PMID: 11739383
- molecular cloning and characterization of a novel class II histone deacetylase PMID: 11861901
- Reduced expression of histone deacetylase 10 is associated lung cancer PMID: 15305372
- Results suggest that the "T" allele of HDAC10-589C>T affect on the increased transcription activity, and might accelerate HCC development through increased expression of HDAC10. PMID: 17892858
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亞細(xì)胞定位：Cytoplasm. Nucleus.
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蛋白家族：Histone deacetylase family, HD type 2 subfamily
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組織特異性：Widely expressed with high levels in liver and kidney.
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數(shù)據(jù)庫鏈接：
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