HCLS1 Antibody

說明書

中文名稱：

HCLS1兔多克隆抗體
貨號：

CSB-PA009155
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P14317
基因名：

HCLS1
別名：

Cortactin like antibody; CTTNL antibody; HCLS 1 antibody; Hcls1 antibody; HCLS1_HUMAN antibody; Hematopoietic cell specific Lyn substrate 1 antibody; Hematopoietic cell-specific LYN substrate 1 antibody; Hematopoietic lineage cell-specific protein antibody; HS 1 antibody; HS1 antibody; LckBP1 antibody; OTTHUMP00000215180 antibody; OTTHUMP00000215182 antibody; p75 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from Human Lck BP-1 around the non-phosphorylation site of Y397.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
基因功能參考文獻：
1. these studies indicate HS1 plays an important role in ROR1-dependent Wnt5a-enhanced chemokine-directed leukemia-cell migration. PMID: 28465529
2. SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells. PMID: 25359136
3. Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors. PMID: 23017497
4. interaction of HCLS1 with LEF-1 is essential for G-CSF-triggered myeloid differentiation; data demonstrate the importance of HCLS1 in myelopoiesis in vitro and in vivo PMID: 23001182
5. HS1 overexpressed in leukemic as compared to normal B lymphocytes. PMID: 22768161
6. a novel role for HS1 and its phosphorylation during neutrophil directed migration. PMID: 22679023
7. High HS1 expression predicts poor survival of chronic lymphocytic leukemia patients. PMID: 22333038
8. SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs. PMID: 21287358
9. HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in chronic lymphocytic leukemia. PMID: 20530793
10. substrate for caspase cleavage during apoptosis PMID: 11689006
11. TBB induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. PMID: 11988074
12. found in cell types other than hematopoietic cells PMID: 15754022
13. HS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets PMID: 15795233
14. The HS1 coiled-coil region acts synergistically with the repeat domain in the modulation of the Arp2/3 complex-mediated actin polymerization. PMID: 16157603
15. HS1 may play a role in cytoskeleon organization in B-cells and leukemic B-cells PMID: 17508001
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亞細胞定位：

Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion.
組織特異性：

Expressed only in tissues and cells of hematopoietic origin.
數據庫鏈接：

HGNC: 4844

OMIM: 601306

KEGG: hsa:3059

STRING: 9606.ENSP00000320176

UniGene: Hs.14601

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