HBE1 Antibody

說明書

中文名稱：

HBE1兔多克隆抗體
貨號：

CSB-PA010153GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P02100
基因名：

HBE1
別名：

Epsilon-globin antibody; HBE_HUMAN antibody; HBE1 antibody; Hemoglobin epsilon chain antibody; Hemoglobin subunit epsilon antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human HBE1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.
基因功能參考文獻：
1. epsilon-globin expression is regulated by SUV4-20h1. PMID: 26802048
2. These data indicate that HP1-gamma is a novel epigenetic repressor of epsilon-globin gene expression. PMID: 28154185
3. Fetal varepsilon-globin gene expression is significantly greater than adult expression and is increased in maternal plasma compared to non-pregnant samples. PMID: 27002261
4. findings indicate the Xmn1-Ggamma polymorphism is likely to be one factor that influences the production of HbF in beta-thalassemia/HbE patients, but not in homozygous HbE patients PMID: 25043956
5. Data indicate that Myb and BCL11A cooperate with DNMT1 to achieve developmental repression of embryonic and fetal beta-like human transgenic globin genes in the adult erythroid environment. PMID: 24371119
6. Data indicate that in embryonic stem cells (hESCs)-derived erythroblasts where both epsilon and gamma globin were active, epsilon globin was immediately silenced upon transfer, whereas gamma globin continued to be expressed for months. PMID: 23993951
7. A plasma proteome analysis is performed to identify differentially expressed proteins compared between normal subjects and patients with mild and severe forms of beta-thalassemia/hemoglobin E (Hb E). PMID: 23161390
8. In the present study, involving the characterization of mutations in transfusion-dependent thalassemia in the Gwalior-Chambal region of Central India, Hb E [beta26(B8)Glu-->Lys, GAG>AAG] was found in high frequency. PMID: 22738610
9. the observed in vivo RBC mild oxidative stress arises, at least in part, from the molecular consequences of the HbE mutation. PMID: 22260787
10. investigation of interaction of HbE w/ other abnormal hemoglobins found in India isolated by cation exchange chromatography; interactions complicate Hb isolation and thus diagnosis of hemoglobinopathies/beta-thalassemias in heterozygous patients PMID: 21986214
11. Erythroblasts from beta-thalassemia/Hb E patients only show activation of the unfolded protein response pathway in response to internal stress, whereas normal erythroblasts respond to both internal and external stress. PMID: 20015891
12. patients with hemoglobin Ebeta thalassemia have a significant decrease in the oxygen affinity of their hemoglobin, that is an increased P(50) value, in response to anemia. PMID: 20833979
13. The frequency of the Ggamma-158(C-->T) polymorphism was relatively high in Southern Chinese patients with HbE/beta-thalassemia major. PMID: 20822527
14. Crystallization and X-ray structure of this protein, isolated from blood of beta-thalassemic patients PMID: 12659864
15. HbE carrier status has been shown to confer protection against Plasmodium falciparum malaria PMID: 15114532
16. Genomic and phylogenetic footprinting at the epsilon-globin silencer region in human cells PMID: 15157738
17. The crystal structure of HbE at 1.74 angstrom resolution in R2 state is used to provide probable explanations of the thermal stability and instability of HbE. PMID: 15449937
18. Mutation screening identified no sequence variations apart from the expected 5'epsilon /HincII polymorphism, suggesting that genomic alterations in the HBE1 gene are most likely incompatible with normal erythropoiesis and proper embryonic development PMID: 16432873
19. results suggest in the context of the whole beta-globin locus, other proximal & upstream epsilon promoter elements & competition by downstream globin genes contribute to silencing of epsilon-globin in cells of definitive erythropoiesis [epsilon-globin] PMID: 16514181
20. We discussed these results in the context of intergenic transcription and chromatin opening in the beta-globin gene cluster. PMID: 16620781
21. The epsilon-globin mRNA is modestly unstable in immature, transcriptionally active erythroid cells, but that this characteristic has relatively little impact on the accumulation of epsilon-globin mRNA at subsequent stages of terminal differentiation. PMID: 17003365
22. The epsilon-globin gene differs in its distance sensitivity to the locus control region from the other beta-like globin genes, which is, at least in part, determined by the transcription factor EKLF. PMID: 17548470
23. the HbA/HbE polymorphism would not be a major genetic factor influencing the onset of cerebral malaria in Thailand. PMID: 18787944
24. The slightly increased levels of Hb A(2), 3.5% +/- 0.4%, which is shown in the carriers of Hb E, confirm that Hb E is the silent phenotype of beta(+)-thalassemia. PMID: 18940720
25. It is necessary to perform a comprehensive DNA analysis for alpha-thalassemia in cases of homozygous HbE when their partner is suspected of having alpha-thalassemia 1 gene. PMID: 19323016
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蛋白家族：

Globin family
組織特異性：

Red blood cells.
數據庫鏈接：

HGNC: 4830

OMIM: 142100

KEGG: hsa:3046

STRING: 9606.ENSP00000292896

UniGene: Hs.655195

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