Gstp1 Antibody, Biotin conjugated

說明書

中文名稱：

Gstp1兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA009989HD01MO
規(guī)格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Gstp1 Polyclonal antibody
Uniprot No.：

P19157
基因名：

Gstp1
別名：

Gstp1 antibody; GstpibGlutathione S-transferase P 1 antibody; Gst P1 antibody; EC 2.5.1.18 antibody; GST YF-YF antibody; GST class-pi antibody; GST-piB antibody; Preadipocyte growth factor antibody
宿主：

Rabbit
反應種屬：

Mouse
免疫原：

Recombinant Mouse Glutathione S-transferase P 1 protein (2-210AA)
免疫原種屬：

Mus musculus (Mouse)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
基因功能參考文獻：
1. Expression of both wild-type and catalytically-inactive Y7F mutant GSTP significantly attenuated LPS- or IKKbeta-induced production of GM-CSF. These studies indicate a complex role for GSTP in modulating NF-kappaB, which may involve S-glutathionylation of IKK proteins, and interaction with NF-kappaB family members. PMID: 27058114
2. GSTP can exert redox regulation in the oxidative ER environment and indicate that, within the ER, GSTP influences the cellular consequences of the UPR through S-glutathionylation of a series of key interrelated proteins. Antioxid. PMID: 26838680
3. our study reveals the novel role of GSTP1 in regulation of iNOS by affecting S-nitrosylation, dimerization, and stability. PMID: 26361746
4. These observed differences contribute to our understanding of how genetic ablation of GSTP causes different levels of myeloproliferation and migration [corrected] PMID: 25216273
5. GSTP1 expression in retina increases with developmental age in mice and accompanies murine retinal maturation. PMID: 24664677
6. GSTP knock-out mice display decreased ubiquitination capacity and overall increased susceptibility to oxidative stress. PMID: 23129554
7. Report increased GSTP1 in airways of asthmatic mice. PMID: 23647087
8. DNIC storage function of GST P1-1 and ability of MRP1 to efflux DNICs are vital in protection against NO cytotoxicity PMID: 22084240
9. Gst-pi expression of the prostate cancers are dependent on metastatic site. PMID: 21748757
10. GSTP plays a major role in carcinogenesis distinct from its role in detoxification and provides evidence that the enzyme is a key determinant of the proinflammatory tumor environment. PMID: 21975931
11. This study analysed the kinetic behaviour of all the various cysteine to alanine mutants of Gstp1. These mutations introduce cooperativity and a novel 'ping pong' mechanism in the case of the C169A mutant. PMID: 21134126
12. Sequential catalysis of Aldr1 by glutathione S-transferase P and glutaredoxin may be a general redox switching mechanism that regulates the reduction of protein sulfenic acids to cysteines regulates the reduction of protein sulfenic acids to cysteines PMID: 20538586
13. role in activating Pi-class glutathione S-transferase gene in conjunction with androgens PMID: 12023900
14. Differential expression of GSTpi contributes to the sensitivity to xenobiotics in the substantia nigra and may influence the pathogenesis of reactive oxygen species-induced neurological disorders including Parkinson's disease. PMID: 17267597
15. GSTP1 attenuates the severity of allergic airways disease. However, the efficacy of GSTP1 correlated with mouse strain-dependent variation in Gstp1 expression. PMID: 18787219
16. Results suggest that GSTpi expression may be part of the mechanism underlying the ability of glial cells to elicit protection against the mechanisms involved in MPTP-induced neuronal death. PMID: 18792812
17. GSTP1 prevented LPS-induced TNF-alpha, IL-1beta, MCP-1 and NO production. PMID: 18962899
18. Catalysis of S-glutathionylation at low pK cysteines in proteins is a novel property for GSTpi PMID: 18990698
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亞細胞定位：

Cytoplasm. Mitochondrion. Nucleus.
蛋白家族：

GST superfamily, Pi family
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

KEGG: mmu:14870

STRING: 10090.ENSMUSP00000129565

UniGene: Mm.299292

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