GZMK Antibody
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中文名稱：GZMK兔多克隆抗體
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貨號：CSB-PA002797
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of Jurkat cells using Granzyme K Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：Fragmentin 3 antibody; Fragmentin-3 antibody; Fragmentin3 antibody; GRAK_HUMAN antibody; Granzyme 3 antibody; granzyme K (granzyme 3; tryptase II) antibody; granzyme K (serine protease; granzyme 3; tryptase II) antibody; Granzyme K antibody; Granzyme K precursor antibody; Granzyme-3 antibody; Granzyme3 antibody; GranzymeK antibody; GZMK antibody; NK TRYP 2 antibody; NK TRYP2 antibody; NK tryptase 2 antibody; NK-TRYP-2 antibody; NK-tryptase-2 antibody; NKTRYP2 antibody; Serine protease granzyme 3 antibody; TRYP 2 antibody; TRYP2 antibody; Tryptase II antibody; TryptaseII antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human Granzyme K.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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基因功能參考文獻(xiàn)：
- Extracellular granzyme K mediates endothelial activation through the cleavage of PAR-1. PMID: 26936634
- Extracellular GrK is an unexpected direct modulator of lipopolysaccharide-TLR4 signaling during the antimicrobial innate immune response. PMID: 24711407
- Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56(bright) natural killer (NK) cells toward activated T cells. PMID: 21666061
- Gr3 proenzymes is activated by cathepsin C which concomitantly decreased the molecular weight to that of active Gr3. PMID: 20377743
- The 2.2-A crystal structure reveals a rigid zymogen with unusual features PMID: 12384499
- The present findings thus introduce the possibility that human beta-tryptase, after mast cell degranulation and exposure to neutral pH in the tissue, may dissociate into active monomers with properties that are distinct from the tetrameric counterpart. PMID: 12387726
- We found human GzmK triggers rapid cell death independently of caspase activation. The features of death are characterized by rapid externalization of phosphatidylserine, nuclear morphological changes and single-stranded DNA nicks. PMID: 17008916
- Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis. PMID: 17438453
- p53 is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy. PMID: 19201868
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亞細(xì)胞定位：Secreted. Cytoplasmic granule.
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蛋白家族：Peptidase S1 family, Granzyme subfamily
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組織特異性：Expressed in lung, spleen, thymus and peripheral blood leukocytes.
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數(shù)據(jù)庫鏈接：
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