GTF2F1 Antibody, Biotin conjugated

說明書

中文名稱：

GTF2F1兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA010004HD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GTF2F1 Polyclonal antibody
Uniprot No.：

P35269
基因名：

GTF2F1
別名：

2810405L04Rik antibody; BTF4 antibody; C76800 antibody; General transcription factor IIF 74 kDa subunit antibody; General transcription factor IIF subunit 1 antibody; General transcription factor IIF; polypeptide 1; 74kDa antibody; Gtf2f1 antibody; MGC94148 antibody; OTTHUMP00000237859 antibody; RAP74 antibody; T2FA_HUMAN antibody; TF2F1 antibody; TFIIF antibody; TFIIF-alpha antibody; Transcription initiation factor IIF subunit alpha antibody; Transcription initiation factor RAP74 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human General transcription factor IIF subunit 1 protein (1-249AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
基因功能參考文獻：
1. An AR motif of the transactivation domain has been identified that contributes to transcriptional activity by recruiting the C-terminal domain of subunit 1 of the general transcription regulator TFIIF. PMID: 29225078
2. These results suggest that Mediator structural shifts induced by activator binding help stably orient pol II prior to transcription initiation within the human mediator-RNA polymerase II-TFIIF assembly. PMID: 22343046
3. Gdown1 competes with TFIIF for binding to the RPB1 and RPB5 subunits of Pol II, thereby inhibiting an essential function of TFIIF in preinitiation complex assembly. PMID: 22244332
4. role of associated carboxyl-terminal domain phosphatase in dephosphorylating phosphoserines 2 and 5 of RNA polymerase II PMID: 12351650
5. The alpha 1 helix of human RAP74 has an important role in the initiation and elongation of RNA chains PMID: 12354769
6. The NMR solution structure of the C-terminal domain of RAP74 has been determined, and NMR methods have been used to map the binding sites of the C-terminus of CTD phosphatase/FCP1 on the RAP74 C-terminal fragment. PMID: 12578358
7. cocrystal structure of the winged-helix domain of human RNA polymerase II-associating protein 74 bound to the alpha-helical C terminus of human FCP1 PMID: 12591941
8. NMR structure of a complex containing this TFIIF subunit and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. PMID: 12732728
9. Interaction of TFIIF subunit RAP74 with recombinant androgen receptor N-terminal activation domain AF1 leads to imposition of helical structure on the AF1 domain. PMID: 15023052
10. TFIIF supports elongation and suppresses pausing by stabilizing the post-translocated elongation complex PMID: 15351637
11. alpha1-Helix of RAP74 is important for supporting NTP-driven translocation by RNAP II. PMID: 15831464
12. TFIIF and Rpb7 are involved in both early and late transcriptional stages PMID: 17848138
13. Mutated hydrophobic residues in RAP74 C-terminal structure disrupt secondary structure elements, showing that binding of the androgen receptor N-terminal domain depends upon helix 3 in the winged-helix domain of the RAP74 C-terminal domain polypeptide. PMID: 18284209
14. NMR and thermodynamic studies further elucidate the complex molecular mechanism by which TFIIF and FCP1 cooperate for RNAPII recycling. PMID: 19215094
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亞細胞定位：

Nucleus.
蛋白家族：

TFIIF alpha subunit family
數據庫鏈接：

HGNC: 4652

OMIM: 189968

KEGG: hsa:2962

STRING: 9606.ENSP00000377969

UniGene: Hs.68257

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