GSPT2 Antibody
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中文名稱：GSPT2兔多克隆抗體
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貨號：CSB-PA009967GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：GSPT2
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別名：eRF3b antibody; ERF3B_HUMAN antibody; Eukaryotic peptide chain release factor GTP-binding subunit ERF3B antibody; Eukaryotic peptide chain release factor subunit 3b antibody; G1 to S phase transition 2 antibody; G1 to S phase transition protein 2 homolog antibody; Gspt2 antibody; GST2 antibody; peptide chain release factor 3 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human GSPT2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
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基因功能參考文獻：
- Loss of GSPT2 and/or MAGED1 function may contribute to the intellectual disability. PMID: 28414775
- The survivin and eRF3 complex may function in spindle formation and segregation of chromosomes and cytokinesis. PMID: 23377885
- The tumor marker eRF3B can change the cell cycle and influence the phosphorylation status of 4E-BP1. PMID: 24466059
- The proteolytic cleavage of eRF3a and eRF3b into p-eRF3 leads to release an amino-terminal fragment containing nuclear export signal to allow the relocalization of eRF3 into the nucleus to interact with the p14ARF. PMID: 24569073
- eRF3b can substitute for eRF3a in its translation termination function. PMID: 15987998
- eRF1's M domain contacts eRF3's GTPase domain PMID: 19417105
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亞細胞定位：Cytoplasm.
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蛋白家族：TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, ERF3 subfamily
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組織特異性：Highly expressed in IUCC stage II colorectal cancer (CRC).
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數據庫鏈接：
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