GRPR Antibody

說明書

中文名稱：

GRPR兔多克隆抗體
貨號：

CSB-PA156499
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA156499(GRPR Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA156499(GRPR Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human hepatocellular carcinoma tissue, A549 cells, Primary antibody: CSB-PA156499(GRPR Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P30550
基因名：

GRPR
別名：

BB2 antibody; Bombesin BB2 receptor antibody; bombesin receptor 2 antibody; Gastrin Releasing Peptide Receptor antibody; Gastrin-releasing peptide receptor antibody; GRP preferring bombesin receptor antibody; GRP R antibody; GRP-preferring bombesin receptor antibody; GRP-R antibody; Grp/bombesin receptor antibody; Grpr antibody; GRPR_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human GRPR
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:200-1:1000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory.
基因功能參考文獻：
1. Expression of Gastrin-Releasing Peptide Receptor in Breast Cancer and Its Association with Pathologic, Biologic, and Clinical Parameters PMID: 28280221
2. GRP-R regulates glucose metabolism in neuroblastoma by modulating HIF-1alpha, PDK4 and PDP2. PMID: 25630799
3. BBS caused a significant increase in Shh gene transcription and protein secretion that was dependent on BBS-induced GPCR/Galphaq-//Rho mediated activation of nuclear factor kappaB (NFkappaB), which can stimulate a NF-kappaB response element in the Shh gene promoter PMID: 24747971
4. GRPR is highly expressed in epidermoid carcinoma of the anal canal, suggesting this receptor might have a role in anal carcinogenesis. PMID: 23958544
5. a key mechanism for GRPR-regulated colon cancer cell migration through the Galpha13-PRG-RhoA-ROCK pathway. PMID: 24958816
6. GRPR expression was more pronounced in an advanced-stage lung cancer PMID: 24377816
7. integrin ss1 subunit critically regulates GRP-R-mediated neuroblastoma cell migration and invasion PMID: 23889963
8. Elevated buccal GRPR espression was significantly associated with squamous cell carcinoma of the head and neck. PMID: 22431275
9. These findings highlight the role of GRPR signaling in sepsis outcome. PMID: 22735756
10. Protein kinase C is critically responsible for rapid VEGF secretion by gastrin-releasing peptide receptor signaling in neuroblastoma cells PMID: 23155231
11. High GRPR is associated with prostate carcinoma. PMID: 22248281
12. Bronchial gastrin-releasing peptide receptor expression was significantly associated with lung cancer in a multivariable logistic regression model adjusted for age, sex, smoking status and pulmonary function. Lung cancer risk was not modified by sex. PMID: 22296774
13. Concomitant vascular GRP-receptor and VEGF-receptor expression in human tumors provides molecular basis for dual targeting of tumoral vasculature. PMID: 21605611
14. This study is the first to confirm the presence of gastrin-releasing peptide receptor in human glioma specimens and normal human neurons. PMID: 20211708
15. The results suggest that brain-derived neurotrophic factor/TrkB and cAMP phosphodiesterase-4, but not the gastrin-releasing peptide receptor, regulate the viability of medulloblastoma cells. PMID: 19642024
16. hGRP-R activation stimulated sustained cyclic AMP response element binding protein (CREB) phosphorylation and transactivation in duodenal cancer cells through a protein kinase C and partially p38 mitogen-activated protein kinase-dependent pathway. PMID: 12220644
17. Bombesin-dependent activation (through GRP receptor) of the transcription factor Elk-1 and significant increase of cell proliferation in prostate cancer cell lines PMID: 12409226
18. accumulation of mutations within the GRPR gene allows for the dedifferentiation of tumor cells within any particular colon cancer; poorly-differentiated tumor cells within any individual cancer may arise clonally from better-differentiated precursors PMID: 12720295
19. Increased gastrin-releasing peptide (GRP) receptor expression in small cell lung cancer cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11)-induced growth inhibition PMID: 12771999
20. The expression of GRP-R in uterine tissue during specific phases of the cycle suggests a timely precise physiological action of GRP in these targets; in certain uterine neoplasms, the GRP-R overexpression may contribute to tumor development PMID: 15941862
21. Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells PMID: 15967120
22. GRP appears to rescue NSCLC cells exposed to gefitinib through release of amphiregulin and activation of the Akt pathway, suggesting GRPR and/or EGFR autocrine pathways in NSCLC cells may modulate therapeutic response to EGFR inhibitors. PMID: 17349623
23. The large amounts of GRP-receptors in ovarian tumor vessels suggest a role in tumoral vasculature and possibly angiogenesis. PMID: 17726264
24. There is a potential role of C6S and L181F mutations on GRPR function, and possibly in the pathogenesis of the autistic disorders. PMID: 18393381
25. CREB is a critical regulator of human GRP-R expression in gastrointestinal cancer and might be activated through different upstream intracellular pathways PMID: 18483184
26. Widespread GRPR expression in human cervical cancer. PMID: 18497507
27. These findings demonstrate that GRP and GRP-R have important oncogenic properties beyond their established mitogenic functions. PMID: 18753628
28. Gastrin-releasing peptide receptor is expressed in the vast majority of lymph node metastases and in 52.9% of bone metastases of prostate cancer. PMID: 19343734
29. High expression of gastrin-releasing peptide receptors is associated with the vascular bed of urinary tract cancers. PMID: 19478282
30. In MDA-MB-231 breast cancer cells, GRP-R and EGF-R synergize to regulate cell migration and IL-8 expression, but not cell proliferation. PMID: 19631337
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.
數據庫鏈接：

HGNC: 4609

OMIM: 305670

KEGG: hsa:2925

STRING: 9606.ENSP00000369643

UniGene: Hs.567282

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