GRIK1 Antibody

說明書

中文名稱：

GRIK1兔多克隆抗體
貨號：

CSB-PA008963
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P39086
基因名：

GRIK1
別名：

EAA3 antibody; EEA3 antibody; Excitatory amino acid receptor 3 antibody; GLR5 antibody; GluR-5 antibody; GluR5 antibody; GluR6 antibody; GluR7 antibody; Glutamate receptor 5 antibody; Glutamate receptor antibody; Glutamate receptor ionotropic kainate 1 antibody; GRIK1 antibody; GRIK1_HUMAN antibody; Human glutamate receptor GLUR5 antibody; ionotropic kainate 1 antibody; OTTHUMP00000096569 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the N-terminal region of Human GluR-5.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
基因功能參考文獻：
1. DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction. PMID: 27447243
2. The findings reported here suggest that, in participants with the GRIK1 rs2832407*CC genotype, topiramate treatment enhances self-efficacy and reduces heavy drinking. PMID: 25496338
3. Findings indicate that SNPs in the GRIK1 gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk. PMID: 26289945
4. Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors PMID: 26277340
5. In the present study, we have shown that gene-gene interaction of components of different systems associated with nicotine reinforcing effects, such as OPRM1 and GRIK1, rather than one gene polymorphism, is associated with smoking behavior. PMID: 25941919
6. This found that, among rs2832407*C of GRIK1 homozygotes, topiramate treatment produced the greatest reductions in the expected positive effects of drinking and desire to drink during the treatment period. PMID: 24786948
7. These results suggest that the effect of topiramate on drinking behavior, in which the GluK1-containing kainate receptor appears to play a key role, can be dissociated from its effect on weight. PMID: 24978347
8. Topiramate treatment for alcohol dependence was significantly more effective in rs2832407 C-allele homozygotes. PMID: 24525690
9. Reduced Homer binding to mGluR5 supports an inhibitory role for Homer interactions with mGluR5 in mediating neuropathy. PMID: 23685007
10. Using the SNaPshot assay, we present evidence for allelic nondisjunction at rs363506 in the GRIK1 gene and rs2834235 and rs7283354 in the GARS-AIRS-GART gene in Down syndrome in India. PMID: 22931243
11. The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV-related HCC, suggesting the involvement of glutamate signaling in the development of HBV-related HCC. PMID: 22807686
12. GRIK1 rs469472 to be possibly associated with schizophrenia in our independent case-control and family samples PMID: 22730074
13. Presynaptic Gluk1 kainate receptors that reduce transmitter release downstream are independent of divalent calcium ion Ca2+ influx. PMID: 20848601
14. The amino acid sequence of the GluK1 kainate receptor near or within the carboxyl-terminal endoplasmic reticulum retention signal sequence, which affects receptor trafficking and/or expression, does not affect channel gating properties. PMID: 22191429
15. The GRIK1 promoter is activated by Trichostatin A (TSA) treatment and by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
16. findings show GluR5 was upregulated in the hippocampus, but not in the temporal neocortex, of patients with temporal lobe epilepsy (TLE)compared to controls; mossy fiber sprouting in the hippocampus of TLE patients was correlated with GluR5 upregulation PMID: 19941835
17. Variation in the 3' portion of the gene encoding the GluR5 kainate receptor subunit contributes to the risk for alcohol dependence. PMID: 19320626
18. GluK1 kainate receptor polymorphisms are associated with Down syndrome. PMID: 19893199
19. GRIK1 does not play a major role in schizophrenia pathogenesis in the Japanese population PMID: 11702055
20. there are trafficking signals in the C-terminal domain of GluR5-2b; alternative splicing is an important mechanism regulating KAR function PMID: 14527949
21. Two amino acids,competitive GluR5 KA receptor antagonists, exhibited high GluR5 receptor affinity over other glutamate receptors. PMID: 15974569
22. This kainate receptor subunit appears to be selectively altered in the anterior cingulate cortex in schizophrenia and bipolar disorder. PMID: 17698324
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
蛋白家族：

Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK1 subfamily
組織特異性：

Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
數據庫鏈接：

HGNC: 4579

OMIM: 138245

KEGG: hsa:2897

STRING: 9606.ENSP00000382791

UniGene: Hs.664641

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