GRIA3 Antibody

說明書

中文名稱：

GRIA3兔多克隆抗體
貨號：

CSB-PA009900KA01HU
規格：

￥2640
圖片：
Western blot analysis of brian cell lysate using GRIA3 antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P42263
基因名：

GRIA3
別名：

AMPA 3 antibody; AMPA selective glutamate receptor 3 antibody; AMPA-selective glutamate receptor 3 antibody; dJ1171F9.1 antibody; GluA3 antibody; GLUK3 antibody; GluR 3 antibody; GLUR C antibody; GLUR K3 antibody; GluR-3 antibody; GluR-C antibody; GluR-K3 antibody; GLUR3 antibody; GLURC antibody; Glutamate ionotropic receptor AMPA type subunit 3 antibody; Glutamate receptor 3 antibody; Glutamate receptor C antibody; Glutamate receptor ionotrophic AMPA 3 antibody; Glutamate receptor ionotropic antibody; Glutamate receptor subunit 3 antibody; Glutamate receptor; ionotropic; AMPA 3 antibody; GRIA 3 antibody; Gria3 antibody; GRIA3_HUMAN antibody; Ionotrophic Glutamate Receptor antibody; MRX94 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Recombinant protein of Human GRIA3
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
基因功能參考文獻：
1. Results suggest a role for GluA3 channel activity in the regulation of sleep behavior in both mice and humans. PMID: 29016847
2. miR-330-3p up-regulated the total DNA methylation in non-small cell lung cancer cells, and co-IP-demonstrated GRIA3 was directly related with DNMT1 and DNMT3A. GRIA3 is a direct target of miR-330-3p. PMID: 28629431
3. This study showed the lower GluA3 mRNA levels in pregnant women. PMID: 28284346
4. the impaired surface expression of homomeric GluA3 receptors is caused by nonproductive assembly and aggregation to which LBD residues Tyr-454 and Arg-461 strongly contribute. PMID: 26912664
5. This study demonstrated that the GRIA3 protein was altered in auditory cortex patient with schizophreia. PMID: 25433904
6. An association was observed in migraine patients with the GRIA3 single nucleotide polymorphism rs3761555. PMID: 23772601
7. The ionotrophic glutamate receptors AMPA3 and AMPA3 were decreased in hippocampus in patient with multiple sclerosis. PMID: 23595422
8. The rs557762 and the TT haplotype in the 11th haplotype block of the GRIA3 gene were associated with feelings of guilt in females. PMID: 22429480
9. the promoter methylation of the GMR2 and GMR5 genes greatly decreased the risk of schizophrenia, and the expression level of the GRM2, GRM5, and GRIA3 genes increased significantly in patients in comparison to healthy controls. PMID: 23149219
10. SNP rs687577 associated with sleep duration and depression risk in Finnish women PMID: 21966062
11. GRIA3 plays a role as a mediator of tumor progression in pancreatic cancer downstream CUX1. PMID: 20689760
12. Two variants in the regulative regions of GRIA1 (rs2195450) and GRIA3 (rs3761555) genes resulted strongly associated with MA (P = 0.00002 and P = 0.0001, respectively), but not associated with MO PMID: 20579352
13. AQP3 gene isn't the responsible gene for this pedigree with auditory neuropathy. PMID: 20564826
14. This study demonistrated that the level of metabotropic glutamate receptor 2/3 is elevated in the prefrontal cortex in patient of major depression disorder. PMID: 19945495
15. The mGlu3 receptor is located on a number of GABAergic interneurons throughout the brain. mGlu3 receptor is one of two primary mGlu receptors that modulate the function of glia. The mGlu3 receptor is present as a postsynaptic receptor as well. PMID: 19933774
16. T lymphocytes from normal individuals, an alloprimed human T cell clone, and human T leukemia (Jurkat) cells all express high levels of GluR3, identical in sequence with brain GluR3. PMID: 12682273
17. cleavage and release to the extracellular milieu of the GluR3B peptide may in principle increase its antigenicity PMID: 17202328
18. study provides the genetic and functional evidence that mutant iGluR3 with altered kinetic properties is associated with moderate cognitive impairment in humans PMID: 17989220
19. results support the involvement of genes GRIA3 and GRIK2 in antidepressant treatment-emergent suicidal ideation PMID: 18593792
20. Aberrant GRIA3 transcripts with multi-exon duplications in a family with X-linked mental retardation are reported. PMID: 19449417
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相關疾病：

Mental retardation, X-linked 94 (MRX94)
亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
蛋白家族：

Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA3 subfamily
數據庫鏈接：

HGNC: 4573

OMIM: 300699

KEGG: hsa:2892

STRING: 9606.ENSP00000264357

UniGene: Hs.377070

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