GREB1 Antibody
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中文名稱：GREB1兔多克隆抗體
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貨號：CSB-PA233008
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA233008(GREB1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA233008(GREB1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：GREB1
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別名：5730583K22Rik antibody; 9130004E13 antibody; AF180470 antibody; AU023194 antibody; Gene regulated by estrogen in breast cancer protein antibody; Gene regulated in breast cancer 1 protein antibody; GREB 1 antibody; Greb1 antibody; GREB1_HUMAN antibody; KIAA0575 antibody; mKIAA0575 antibody; OTTHUMP00000180581 antibody; Protein GREB1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthetic peptide of Human GREB1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
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基因功能參考文獻：
- GREB1 is a novel progesterone-responsive gene required for endometrial stromal decidualization. PMID: 28911214
- The aim of this study was to determine if genetic variation within GREB1 was associated with BMD variation. PMID: 28293781
- Whole exome sequence analysis of two families with renal agenesis identified a single candidate gene, GREB1L. Data implicates GREB1L as a coactivator for RARs. PMID: 28739660
- Which were rescued by wild-type human GREB1L mRNA. PMID: 29100090
- A significant association between GREB1L variants and BKA. PMID: 29100091
- the GREB1 region on chromosome 2p25.1 and the GREB1 gene may play a role in endometriosis risk PMID: 25788566
- GREB1 is a critical mediator of both the estrogen-stimulated proliferation of breast cancer cells and the androgen-stimulated proliferation of prostate cancer cells PMID: 24998469
- The expression of Greb1 was up-regulated in mouse tumors treated with E2 and was overexpressed in human ovarian cancers relative to human ovarian surface epithelium, suggesting a role for GREB1 in human ovarian tumor progression. PMID: 24469735
- RAD54B and GREB1 gene polymorphisms may not be associated with PCOS in the Han Chinese population. PMID: 23876972
- GREB1 is one of the central estrogen-specific ER cofactors, where it functions to mediate interactions between the ER and additional proteins. PMID: 23403292
- GREB1 alpha mRNA/protein expression levels were increased in ectopic tissue in peritoneal endometriosis. PMID: 22884659
- in ER-positive breast cancer cells, LRH-1 promotes cell proliferation by enhancing ERalpha mediated transcription of target genes such as GREB-1 PMID: 22359603
- Tissue expression of GREB1 is associated with organ-confined prostate cancer and may constitute a gene associated with a favorable prognosis. PMID: 19945309
- Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). PMID: 21577013
- Characterize a monoclonal antibody that recognizes GREB1 protein in breast cancer cells. PMID: 19842031
- GREB1 is critically involved in the estrogen induced growth of breast cancer cells. PMID: 15986123
- GREB1 is expressed in proliferating prostatic tissue and prostate cancer, is regulated by androgens, and suppression of GREB1 blocks androgen-induced growth suggesting GREB1 may be critically involved in prostate cancer proliferation. PMID: 16496412
- Data show that the induction of the gene regulated in breast cancer 1 (GREB1) is mediated by binding of estrogen receptor alpha to three consensus estrogen response elements spread over approximately 20 kb of upstream flanking sequences. PMID: 17463000
- estrogen-stimulated GREB1 transcription may involve coordinated ER binding to all three distal consensus ERE motifs PMID: 17666587
- GREB1 is expressed in human skin, and is dose-dependently induced by topical 17-beta-estradiol treatment PMID: 18794456
- Estrogen receptors are recruited at several proximal and distal estrogen response elements upstream of the GREB1 transcription unit. PMID: 15001666
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亞細胞定位：Membrane; Single-pass membrane protein.
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蛋白家族：GREB1 family
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組織特異性：Expressed in proliferating prostatic tissue and prostate cancer.
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數據庫鏈接：
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