GPX2 Antibody, Biotin conjugated
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中文名稱：GPX2兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA009867LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) GPX2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Gastrointestinal glutathione peroxidase antibody; GI GPx antibody; Glutathione peroxidase 2 (gastrointestinal) antibody; Glutathione peroxidase 2 antibody; Glutathione peroxidase gastrointestinal antibody; Glutathione peroxidase related protein 2 antibody; Glutathione peroxidase-gastrointestinal antibody; Glutathione peroxidase-related protein 2 antibody; GPRP antibody; GPRP-2 antibody; GPx 2 antibody; GPx-2 antibody; GPx-GI antibody; GPX2 antibody; GPX2_HUMAN antibody; GSHPx 2 antibody; GSHPx GI antibody; GSHPx-2 antibody; GSHPx-GI antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Glutathione peroxidase 2 protein (71-168AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
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基因功能參考文獻(xiàn)：
- GPx2 may play an important role in the development of nasopharyngeal carcinoma. Furthermore, GPx2 may serve as a prognostic biomarker for NPC patient. PMID: 28453466
- Yes associated protein 1 (YAP) activation led to excessive accumulation of reactive oxygen species (ROS) by downregulating the antioxidant enzyme glutathione peroxidase GPX2 in a manner related to tumor protein p63 blockade. PMID: 28916653
- Results showed that the expression of GPX2 was significantly up-regulated within esophageal squamous cell carcinoma tissues. PMID: 27388201
- Glutathione peroxidase 2 expression is a novel independent prognostic biomarker for gastric carcinoma that may be used to devise personalized therapeutic regimens and precision treatments for this disease PMID: 28631563
- glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients. PMID: 28635398
- Cardamonin exposure and selenium availability regulate expression of HO-1, GPX2 and TrxR1 in human intestinal cells. PMID: 26698667
- GPX2 underexpression is associated with advanced tumor status and implicated unfavorable clinical outcome of UCs, suggesting its role in tumor progression and may serve as a theranostic biomarker of UCs. PMID: 25813210
- high GPx2 expression was associated with early tumor recurrence, particularly in the recently identified aggressive subtype of human colon cancer. PMID: 25261240
- Patients with high GPX2 expression in biopsy specimen had significantly lower prostate-specific antigen recurrence-free survival and overall survival than those with no GPX2 expression. PMID: 24562575
- miR-185 plays a role in up-regulation of GPX2 and SEPHS2 expression. PMID: 23934683
- A role of GPx2, TrxR2 and TrxR3 in proliferation, apoptosis and, therefore, also during cancer development. PMID: 22683372
- A GPx2-independent decrease in tumor development by selenium (Se) and detrimental effects of the Nrf2-activator sulforaphane in moderate Se deficiency. PMID: 22758632
- Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue PMID: 11811519
- Data suggest that some antioxidants may exert their anti-inflammatory and anticarcinogenic effects not only by induction of phase 2 enzymes but also by the up-regulation of the selenoprotein GI-GPx by Nrf2 binding. PMID: 15923610
- some isoforms of p63 serve as a pro-survival factor by up-regulating GPX2 to reduce the p53-dependent oxidative stress-induced apoptotic response PMID: 16446369
- Glutathione peroxidase 2 (GPX2) is the major oxidative stress-inducible cellular GPX isoform in the lungs, and its basal as well as inducible expression is dependent on Nrf2. PMID: 16794261
- SNPs involving the GSTP1, MnSOD and GPX2 genes were not associated with Barrett's esophagus or esophageal adenocarcinoma PMID: 17277236
- Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin. PMID: 17937616
- Gpx2 is an overexpressed gene in human breast cancers PMID: 18056462
- Results show that GPx2 by compartmentalized removal of hydroperoxides silences COX-2 activity and suppresses PGE(2)-dependent COX-2 and mPGES-1 expression. PMID: 18479189
- No significant risk for GPX2 in colorectal adenoma. PMID: 18483336
- Data show that GPx2 inhibits malignant characteristics of tumor cells, migration and invasion, obviously by counteracting COX-2 expression but is required for the growth of transformed intestinal cells and may, therefore, facilitate tumor cell growth. PMID: 19047153
- Knockout studies in mice suggest that Gpx2 mRNA and GPX-2 activity levels are induced by luminal microflora, consistent with a role in suppression of inflammation in the mucosal epithelium during weaning. PMID: 12751789
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亞細(xì)胞定位：Cytoplasm. Note=Mainly cytoplasmic.
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蛋白家族：Glutathione peroxidase family
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組織特異性：Mostly in liver and gastrointestinal tract, not found in heart or kidney.
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