GPR65 Antibody
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中文名稱(chēng)：GPR65兔多克隆抗體
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貨號(hào)：CSB-PA548371
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA548371(GPR65 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA548371(GPR65 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：GPR65; TDAG8; Psychosine receptor; G-protein coupled receptor 65; T-cell death-associated gene 8 protein
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthetic peptide of Human GPR65
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance. May have a role in activation-induced cell death or differentiation of T-cells.
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基因功能參考文獻(xiàn)：
- TDAG8 functions as a contextual tumor suppressor down-regulated in hematological malignancies. PMID: 29017562
- Study results suggest greater T cell death associated gene-8 (TDAG8) expression in patients with panic disorder compared to healthy subjects, and directly link TDAG8 expression and the severity of the panic disorder symptoms PMID: 28736033
- this study establishes a role for GPR65 in inflammatory bowel disease susceptibility and identify lysosomal dysfunction as a potentially causative element in pathogenesis PMID: 27287411
- TDAG8 expression is decreased by more than 50%. PMID: 24152439
- GPR65 is a regulator upstream of MMP3, which is regulated by proton-sensing G-protein-coupled receptors PMID: 23707809
- Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk. PMID: 22685289
- Data suggest that one physiological function of TDAG8 is negative regulation of inflammation by inhibiting production of pro-inflammatory cytokines in T-lymphocytes and macrophages. PMID: 22445881
- These results support the hypothesis that TDAG8 enhances tumor development by promoting adaptation to the acidic environment to enhance cell survival/proliferation. PMID: 20855608
- GPR4 and TDAG8 overexpression in human tumors plays a role in driving or maintaining tumor formation PMID: 15221007
- TDAG8 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine, and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4, and OGR1. PMID: 15326175
- TDAG8 may play biological roles in immune response and cellular transformation under conditions accompanying tissue acidosis. PMID: 15618224
- Expression of TDAG8 by immune cells may regulate responses in acidic microenvironments. PMID: 15665078
- At least partly, TDGA8 mediates extracellular acidification-induced inhibition of proinflammatory cytokine production through the Gs protein/cyclic AMP-dependent protein kinase A signaling pathway in transgenic mouse macrophages. PMID: 19234222
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亞細(xì)胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 1 family
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組織特異性：Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes.
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數(shù)據(jù)庫(kù)鏈接：
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