GPR126 Antibody

說明書

中文名稱：

GPR126兔多克隆抗體
貨號：

CSB-PA002757
規格：

￥1090
圖片：
Western Blot analysis of HuvEc cells using GPR126 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q86SQ4
基因名：

ADGRG6
別名：

adhesion G protein coupled receptor G6 antibody; APG1 antibody; Developmentally regulated G protein coupled receptor antibody; Developmentally regulated G-protein-coupled receptor antibody; dj287g14.2 antibody; DREG antibody; G protein coupled receptor 126 antibody; G-protein coupled receptor 126 antibody; GP126_HUMAN antibody; GPR126 antibody; HBV PreS1 transactivated protein 2 antibody; HBV PreS1-transactivated protein 2 antibody; LCCS9 antibody; OTTHUMP00000017320 antibody; OTTHUMP00000237093 antibody; OTTHUMP00000237094 antibody; OTTHUMP00000237115 antibody; PR126 antibody; Probable G protein coupled receptor 126 [Precursor] antibody; Probable G protein coupled receptor 126 antibody; Probable G-protein coupled receptor 126 [Precursor] antibody; Probable G-protein coupled receptor 126 antibody; PS1TP2 antibody; Vascular inducible G protein coupled receptor antibody; Vascular inducible G protein-coupled receptor antibody; VIGR antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human GPR126.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:5000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis.
基因功能參考文獻：
1. The association of a single nucleotide polymorphism in GPR126 with aggressive periodontitis in a Japanese population. The role of GPR126 in maintaining the homeostasis of periodontal ligament tissues. PMID: 27509131
2. Together, these data uncover Gpr126 as a genetic cause for the pathogenesis of Adolescent idiopathic scoliosis (AIS) and pectus excavatum in a mouse model. PMID: 25954032
3. Genetic variants of GPR126 gene are associated with adolescent idiopathic scoliosis susceptibility in Chinese populations. PMID: 25479386
4. Mutations of GPR126 are responsible for severe arthrogryposis multiplex congenita. PMID: 26004201
5. GPR126 modulates both physiological and pathological angiogenesis through VEGF signaling PMID: 25217645
6. Gpr126 functions in Schwann cells for proper development and myelination through G-protein-signaling pathways. PMID: 24227709
7. A single nucleotide polymorphism in the GPR126 gene is associated with increased susceptibility for adolescent idiopathic scoliosis. [Meta-analysis] PMID: 23666238
8. Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms. PMID: 21929287
9. The PS1TP2 gene was located at 6q24.1, and interacts with leukocyte proteins. PMID: 18304421
10. VIGR represents a novel G protein coupled receptors of the adhesion family, which is unique in its long extra-cellular domain. PMID: 15225624
11. APG1 formed an alpha-helical structure at the C-terminal site and a positive charge cluster at the N-terminal site. PMID: 17109822
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相關疾病：

Lethal congenital contracture syndrome 9 (LCCS9)
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
組織特異性：

Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
數據庫鏈接：

HGNC: 13841

OMIM: 606255

KEGG: hsa:57211

STRING: 9606.ENSP00000356581

UniGene: Hs.743302

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