GOT2 Antibody
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中文名稱：GOT2兔多克隆抗體
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貨號：CSB-PA147812
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA147812(GOT2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA147812(GOT2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) -
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-7: 293T cells, Hela cells, Human fetal liver tissue, mouse spleen tissue, Mouse heart tissue, human fetal brain tissue, hepatocellular carcinoma tissue, Primary antibody: CSB-PA147812(GOT2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：GOT2
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別名：AATM_HUMAN antibody; AL022787 antibody; Aspartate aminotransferase 2 antibody; Aspartate aminotransferase antibody; Aspartate aminotransferase; mitochondrial antibody; Aspartate transaminase 2 antibody; ASPATA antibody; EC 2.6.1.1 antibody; FABP 1 antibody; FABP pm antibody; FABP-1 antibody; FABPpm antibody; Fatty acid binding protein antibody; Fatty acid-binding protein antibody; FLJ40994 antibody; Glutamate oxaloacetate transaminase 2 antibody; Glutamate oxaloacetate transaminase 2; mitochondrial antibody; Glutamate oxaloacetate transaminase; mitochondrial antibody; Glutamic oxaloacetic transaminase 2; mitochondrial (aspartate aminotransferase 2) antibody; Got 2 antibody; GOT2 antibody; KAT4 antibody; KATIV antibody; kynurenine aminotransferase 4 antibody; Kynurenine aminotransferase IV antibody; kynurenine--oxoglutarate transaminase 4 antibody; kynurenine--oxoglutarate transaminase IV antibody; mAspAT antibody; MGC102129 antibody; MGC115763 antibody; mitAAT antibody; mitochondrial antibody; Mitochondrial aspartate aminotransferase antibody; OTTMUSP00000017748 antibody; Plasma membrane fatty acid binding protein antibody; Plasma membrane-associated fatty acid-binding protein antibody; Transaminase A antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human GOT2
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:100-1:300 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
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基因功能參考文獻(xiàn)：
- Study utilizing integrative analysis of transcriptomic, metabolomic, and clinical data propose a model of GOT2 transcriptional regulation, in which the cooperative phosphorylation of STAT3 and direct joint binding of STAT3 and p65/NF-kappaB to the proximal GOT2 promoter are important. Furthermore, high aberrant GOT2 expression is prognostic in diffuse large B-cell lymphoma. PMID: 29666362
- The results of our study on this larger than 5800-patient cohort suggest beneficial effects of high B12 vitamin level, negative effects of high sodium levels or high AST (aspartate aminotransferase) liver enzyme levels to cognition. PMID: 28918286
- Like in adults, FABP seems to be associated with markers of metabolic risk in obese adolescents PMID: 28183455
- Data suggest that, in context of abnormal hepatic lipid accumulation in nonalcoholic fatty liver disease, circulating GOT2 rises due to up-regulation of hepatic expression of GOT2 associated with greater gluconeogenesis and insulin resistance. PMID: 26791191
- A previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection. PMID: 25755250
- High glucose infusion was associated with increased expression of higher plasma membrane-associated fatty acid-binding protein (FABPpm). PMID: 24937540
- The lipid binding process in L-FABP is associated with backbone dynamics. PMID: 22713574
- Frequency of polymorphism are similar in control groups and schizophrenics. PMID: 17728674
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亞細(xì)胞定位：Mitochondrion matrix. Cell membrane.
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蛋白家族：Class-I pyridoxal-phosphate-dependent aminotransferase family
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數(shù)據(jù)庫鏈接：
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