GNMT Antibody

中文名稱：

GNMT兔多克隆抗體
貨號：

CSB-PA009628LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA009628LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA009628LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GNMT Polyclonal antibody
Uniprot No.：

Q14749
基因名：

GNMT
別名：

EC 2.1.1.20 antibody; Epididymis secretory sperm binding protein Li 182mP antibody; Glycine N methyltransferase antibody; Glycine N-methyltransferase antibody; Gnmt antibody; GNMT_HUMAN antibody; HEL S 182mP antibody; OTTHUMP00000016412 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Glycine N-methyltransferase protein (2-295AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GNMT Antibody (CSB-PA009628LA01HU)，的標記方式是Non-conjugated。對于GNMT Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA009628LB01HU	GNMT Antibody, HRP conjugated	ELISA
FITC	CSB-PA009628LC01HU	GNMT Antibody, FITC conjugated
Biotin	CSB-PA009628LD01HU	GNMT Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
基因功能參考文獻：
1. Elevated GNMT protein expression is associated with pathogenesis of hepatocellular carcinoma. PMID: 28205209
2. In men of European descent, the GNMT rs10948059 and short tandem repeat polymorphism 1 were associated with prostate cancer risk. PMID: 24800880
3. GNMT is an androgen receptor-targeted gene with its functional androgen response element located at +19/+33 of the first exon. PMID: 23883094
4. The studies identify GNMT as a direct transcriptional target of the AR. PMID: 23997240
5. DNA hypermethylation plays an important role in the repression of GNMT in hepatocellular carcinoma (HCC), and loss of GNMT in human HCC could promote the establishment of aberrant DNA methylation patterns at specific gene promoters PMID: 23475283
6. single-nucleotide polymorphisms in VEGF, IL-10 and GNMT genes might have a synergistic role in the development of Prostate cancer PMID: 22850906
7. Report SNPs that are highly associated with hepatic GNMT protein expression and the coordinate regulation of MAT1A levels. PMID: 22807109
8. GNMT plays important role in maintaining normal function of brain; lack of GNMT causes dysfunction of important signaling pathways and results in alterations of neurotransmitter secretion as well as changes in neuropsychological behavior. PMID: 22264868
9. GNMT is a crucial regulator in cholesterol metabolism and in inflammation, and contributes to the pathogenesis of atherosclerosis. PMID: 22415010
10. In conclusion, GNMT regulates hepatocellular carcinoma growth in part through interacting with DEPDC6/DEPTOR and modulating mTOR/raptor signaling pathway PMID: 22160218
11. GNMT may represent a novel marker of malignant progression and poor prognosis in prostate cancer PMID: 21572396
12. This study suggests that the glycine N-methyltransferase STRP1 phenotype could modulate urinary 1-hydroxypyrene and 8-hydroxy-2'-deoxyguanosine levels in coke-oven workers exposed to PAHs. PMID: 21691217
13. investigation of role of GNMT in methyl group homeostasis in liver: GNMT affects transmethylation kinetics, SAM synthesis, and conservation of methyl groups by limiting homocysteine remethylation flux; possible role of GNMT inactivation in hepatoma PMID: 21411609
14. compound heterzygotes in the gene that encodes GNMT have evidence of mild liver disease PMID: 11810299
15. Results suggest that GNMT alteration may be an early event in hepatocellular carcinoma development and that GNMT could be a new tumor susceptibility gene for hepatocellular carcinoma. PMID: 12566309
16. GNMT 1289 C-->T polymorphism influences plasma homocysteine and is responsive to folate intake. PMID: 16317120
17. GNMT is destabilized by a mutation. PMID: 17660255
18. Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma. PMID: 18624901
19. GNMT is a tumor suppressor gene for liver cancer, and it is associated with gender disparity in liver cancer susceptibility as shown in humans and in mouse models PMID: 19035462
20. A transgenic mouse model is used together with in vitro methods to study the ability of the GNMT transgene to block the cytotoxic or carcinogenic activity of aflatoxin B1, a known causal agent of human hepatocellular carcinoma. PMID: 19146867
21. Study identified a GNMT transcriptional start site at the 14th position upstream of the ATG codon; results indicate binding of the nuclear factor-Y (NF-Y) transcription factor to the CCAAT box (-71/-67) of the GNMT gene. PMID: 19439180
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相關疾病：

Glycine N-methyltransferase deficiency (GNMT deficiency)
亞細胞定位：

Cytoplasm.
蛋白家族：

Class I-like SAM-binding methyltransferase superfamily, Glycine N-methyltransferase family
組織特異性：

Abundant in liver.
數據庫鏈接：

HGNC: 4415

OMIM: 606628

KEGG: hsa:27232

STRING: 9606.ENSP00000361894

UniGene: Hs.144914

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