GNB4 Antibody, Biotin conjugated
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中文名稱：GNB4兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA862056LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) GNB4 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：G protein beta 4 subunit antibody; GBB4_HUMAN antibody; GNB 4 antibody; Gnb4 antibody; Guanine nucleotide binding protein (G protein) beta polypeptide 4 antibody; Guanine nucleotide binding protein beta 4 subunit antibody; Guanine nucleotide binding protein beta polypeptide 4 antibody; Guanine nucleotide binding protein beta subunit 4 antibody; Guanine nucleotide binding protein subunit beta 4 antibody; Guanine nucleotide-binding protein subunit beta-4 antibody; Transducin beta chain 4 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Guanine nucleotide-binding protein subunit beta-4 protein (105-185AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
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基因功能參考文獻：
- GNB4 is important for growth of breast cancer cells and a potential target for treatment PMID: 30103729
- A novel missense GNB4 variant causes Charcot-Marie-Tooth disease F in two patients, who represent the first record of the disease in the Japanese population. PMID: 28642160
- Suggest Gbeta4gamma1 as a modulator of M3 muscarinic receptor signaling. PMID: 25916507
- Analysis of GNB4 in an additional 88 unrelated CMT individuals uncovered another de novo mutation. PMID: 23434117
- Gbeta4 subunit is coexpressed in physiologically ON-type cone bipolar cells with Ggamma13 and Gbeta3 but is not present in OFF-type bipolar cells. PMID: 12454992
- Gbeta4 is widely expressed, located on chromosome 3 with a genomic structure like Gbeta1 to Gbeta3, but different from Gbeta5 PMID: 12782285
- Intron-1 haplotypes of GNB4 may, thus, serve as predictive markers for progression and survival of patients suffering from bladder cancer. PMID: 18815590
- Intron-1 haplotypes of GNB4 is associated with colorectal carcinoma. PMID: 19414374
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相關(guān)疾病：Charcot-Marie-Tooth disease, dominant, intermediate type, F (CMTDIF)
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蛋白家族：WD repeat G protein beta family
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組織特異性：Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves.
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數(shù)據(jù)庫鏈接：
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