GNAT2 Antibody

中文名稱：

GNAT2兔多克隆抗體
貨號：

CSB-PA009599LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of Hela cells with CSB-PA009599LA01HU at 1:167, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GNAT2 Polyclonal antibody
Uniprot No.：

P19087
基因名：

GNAT2
別名：

ACHM4 antibody; Cone type transducin alpha subunit antibody; GNAT 2 antibody; GNAT C antibody; Gnat2 antibody; GNAT2_HUMAN antibody; GNATC antibody; Guanine nucleotide binding protein (G protein) alpha transducing activity polypeptide 2 antibody; Guanine nucleotide binding protein G t subunit alpha 2 antibody; Guanine nucleotide-binding protein G(t) subunit alpha-2 antibody; Transducin alpha 2 antibody; Transducin alpha-2 chain antibody; Transducin alpha2 antibody; Transducin cone specific alpha polypeptide antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Guanine nucleotide-binding protein G(t) subunit alpha-2 protein (2-139AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GNAT2 Antibody (CSB-PA009599LA01HU)，的標記方式是Non-conjugated。對于GNAT2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA009599LB01HU	GNAT2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009599LC01HU	GNAT2 Antibody, FITC conjugated
Biotin	CSB-PA009599LD01HU	GNAT2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
基因功能參考文獻：
1. The majority (n = 12) of patients were either homozygotes or compound heterozygotes for known achromatopsia alleles, two in CNGB3 (p.T383fsX and p.T296YfsX9) and three in CNGA3 (p.R283Q, p.R427C and p.L527R). PMID: 23362848
2. Single nucleotide polymorphisms in GNAT2 gene is associated with obesity. PMID: 23563607
3. Missense mutations, nonsense mutations, splice mutations, and small deletions and insertions in the affected genes cause achromatopsia. PMID: 21267001
4. Expression of GNAT2 transgene, when found in rod photoreceptor cells rather than in cones, demonstrates different mechanisms of amplification in the body's G-protein alpha cascades and the activation of phosphodiesterase 6. PMID: 20603337
5. Clinical and genetic investigation of a large Tunisian family with complete achromatopsia: identification of a new nonsense mutation in GNAT2 gene. PMID: 21107338
6. mutations in GNAT2 are implicated in achromatopsia PMID: 12077706
7. We detected a deletion of a highly conserved lysine at codon 270 in a critical functional area of the alpha-cone transducin molecule, and therefore is not the disease causing mutation. PMID: 15094710
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相關疾病：

Achromatopsia 4 (ACHM4)
亞細胞定位：

Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment.
蛋白家族：

G-alpha family, G(i/o/t/z) subfamily
組織特異性：

Retinal rod outer segment.
數據庫鏈接：

HGNC: 4394

OMIM: 139340

KEGG: hsa:2780

STRING: 9606.ENSP00000251337

UniGene: Hs.36973

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