GNAL Antibody

中文名稱：

GNAL兔多克隆抗體
貨號：

CSB-PA009592LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Colo320 whole cell lysate
All lanes: GNAL antibody at 4.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45, 53, 21 kDa
Observed band size: 45 kDa

IHC image of CSB-PA009592LA01HU diluted at 1:500 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA009592LA01HU diluted at 1:500 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GNAL Polyclonal antibody
Uniprot No.：

P38405
基因名：

GNAL
別名：

Adenylate cyclase stimulating G alpha protein; olfactory type antibody; Adenylate cyclase-stimulating G alpha protein antibody; DYT25 antibody; G alpha olf antibody; Gnal antibody; GNAL_HUMAN antibody; Guanine nucleotide binding protein (G protein); alpha activating activity polypeptide; olfactory type antibody; Guanine nucleotide binding protein (G protein); alpha stimulating activity polypeptide; olfactory type antibody; Guanine nucleotide binding protein G(olf) subunit alpha antibody; Guanine nucleotide-binding protein G(olf) subunit alpha antibody; olfactory type antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Guanine nucleotide-binding protein G(olf) subunit alpha protein (4-116AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，GNAL Antibody (CSB-PA009592LA01HU)，的標(biāo)記方式是Non-conjugated。對于GNAL Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA009592LB01HU	GNAL Antibody, HRP conjugated	ELISA
FITC	CSB-PA009592LC01HU	GNAL Antibody, FITC conjugated
Biotin	CSB-PA009592LD01HU	GNAL Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
基因功能參考文獻(xiàn)：
1. GNAL mutation may represent one of the rare causative genetic factors of isolated laryngeal dystonia. PMID: 27093447
2. GNAL mutations are not a common cause of dystonia in the Brazilian population PMID: 26810727
3. We report a novel GNAL mutation in Italian family with adult-onset, dominantly-inherited dystonia PMID: 26725140
4. Mutations in the GNAL gene may not be a common cause of isolated dystonia in the Chinese population. PMID: 26365774
5. This study demonstrated that Mutations in GNAL may cause Dystonia. PMID: 25847575
6. identified two novel GNAL mutations: one heterozygous missense variant in GNAL exon 4, c.289A>G. PMID: 25382112
7. The findings of this study further support GNAL as causative gene in adult-onset isolated dystonia. PMID: 24408567
8. This study identified a novel likely disease-causing GNAL mutation in a Serbian patient with cervical dystonia and a classical DYT25 phenotype. PMID: 24729450
9. Primary dystonia in the Amish-Mennonites is genetically diverse and includes not only the THAP1 indel founder mutation but also different mutations in THAP1 and GNAL as well as the TOR1A GAG deletion. PMID: 24500857
10. GNAL variants seem to be a rare cause of primary torsion dystonia in our mainly sporadic German sample. PMID: 24151159
11. Our own data suggest that GNAL mutations do not represent a common cause of dystonia in the U.K. population. PMID: 24222099
12. The GNAL dystonia gene is central for striatal responses to dopamine (DA) and is a component of a molecular pathway already implicated in DOPA-responsive dystonia (DRD). PMID: 24144882
13. GNAL mutations potentially increase ethnic susceptibility to movement disorders induced by dopamine antagonists. PMID: 24535567
14. Mutations in GNAL gene can cause adult-onset primary dystonia in Chinese patients PMID: 23759320
15. Familial adult-onset primary dystonia can result from mutations in GNAL. PMID: 23449625
16. Mutations in GNAL cause primary torsion dystonia. PMID: 23222958
17. these findings provide important clues to understanding physiological functions of XLGalpha(olf). PMID: 22120635
18. investigation of whether polymorphisms in the alpha subunit of the Golf gene (A-->G in intron 3, and T-->G in intron 10) are associated with major depression; additionally tested for a parent-of-origin effect in separated gender groups PMID: 11901355
19. promotes cellular invasion, survival and neuroendocrine differentiation in colon, kidney and prostate epithelial cells PMID: 12037684
20. No support for the hypothesis that the olfactory G-protein gene is a major susceptibility factor for bipolar disorders. PMID: 12782961
21. identified a transcriptional variant of the GNAL gene in chromosome 18p11.2 in susceptibility to bipolar disorder and schizophrenia PMID: 16044173
22. Galpha(olf) variant XLGalpha(olf) interacts with the human adenosine A2A receptor PMID: 16818375
23. We hypothesized that the G(s)-like subunit Galpha(olf), expressed in D1-rich areas of the brain, contributes to the genetic susceptibility of ADHD. We examined the inheritance pattern of 12 GNAL polymorphisms in 258 nuclear families. PMID: 17166517
24. This study provides important clues toward understanding physiological functions of XLGalpha(olf). PMID: 19245791
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相關(guān)疾病：

Dystonia 25 (DYT25)
蛋白家族：

G-alpha family, G(s) subfamily
組織特異性：

Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined.
數(shù)據(jù)庫鏈接：

HGNC: 4388

OMIM: 139312

KEGG: hsa:2774

STRING: 9606.ENSP00000334051

UniGene: Hs.136295

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