GNA15 Antibody

說明書

中文名稱：

GNA15兔多克隆抗體
貨號：

CSB-PA009587ESR2HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA009587ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA009587ESR2HU at dilution of 1:100
其他：

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靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GNA15 Polyclonal antibody
Uniprot No.：

P30679
基因名：

GNA15
別名：

G alpha 15 antibody; G alpha 16 antibody; G alpha-15 antibody; G alpha-16 antibody; G-protein subunit alpha-15 antibody; G-protein subunit alpha-16 antibody; GNA 15 antibody; GNA 16 antibody; GNA15 antibody; GNA15_HUMAN antibody; GNA16 antibody; Gq class antibody; Guanine nucleotide binding protein alpha 15 antibody; Guanine nucleotide binding protein alpha 15 subunit antibody; Guanine nucleotide-binding protein subunit alpha-15 antibody; Guanine nucleotide-binding protein subunit alpha-16 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Guanine nucleotide-binding protein subunit alpha-15 protein (1-374AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
基因功能參考文獻：
1. GNA15 was not expressed in normal neuroendocrine cells but was overexpressed in gastroenteropancreatic neuroendocrine neoplasia cell lines. PMID: 25701539
2. Data indicate the importance of Galpha16 as a downstream effector of the non-canonical Wnt signaling pathway and as a potential therapeutic target for the treatment of non small cell lung cancer. PMID: 24204697
3. G15 ectopic presence could functionally contribute to the transformation process since siRNA-induced depletion of Galpha15 in pancreatic carcinoma cell lines dramatically inhibited anchorage-independent growth and resistance to the lack of nutrients. PMID: 23200847
4. The paper describes G alpha 15 resistance to arrestin-desensitization making it differ from other heterotrimeric G proteins (Gq, Gs, Gi, G12/13 class) PMID: 19275934
5. This paper shows how G alpha 15 and other Gq class members phosphorylate PKD in differing patterns PMID: 22227248
6. This review summarizes the specific features that distinguish Galpha15/GNA15 (G15 alpha subunit) from all other alpha subunits of the Gq class. G15 is a heterotrimeric G protein complex that is named after its alpha subunit. PMID: 20150327
7. beta3 region of Galpha16 is essential for interaction with TPR1 and the subsequent activation of Ras PMID: 21486497
8. Megakaryocytopoiesis was accompanied by down-regulation of the 43 kDa and 46 kDa variants of G16alpha, constant expression of Gsalpha, and up-regulation of Gqalpha and Gialpha1/2. PMID: 11686331
9. role of intracellular loops of cannabinoid CB1 receptor in functional interaction with Galpha16. PMID: 12095632
10. G protein-coupled receptors activate STAT3 via G alpha(16), a G alpha subunit which is primarily expressed in hematopoietic cells. PMID: 12670499
11. Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism PMID: 14551213
12. Results suggest that the G(q) class proteins are degraded through the proteasome pathway and that cellular localization and/or other protein interactions determine their stability. PMID: 16218966
13. Co-stimulation of G(s) and G(q) can result in the fine-tuning of STAT3 activation status, and this may provide the basis for cell type-specific responses following activation of hIP. PMID: 18755267
14. The ability of CCR1 to signal through Galpha(14/16) thus provides a linkage for chemokines to regulate NF-kappaB-dependent responses. PMID: 19687291
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蛋白家族：

G-alpha family, G(q) subfamily
組織特異性：

Specifically expressed in hematopoietic cells. Expressed in epididymis (at protein level).
數(shù)據(jù)庫鏈接：

HGNC: 4383

OMIM: 139314

KEGG: hsa:2769

STRING: 9606.ENSP00000262958

UniGene: Hs.73797

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