GMDS Antibody, Biotin conjugated
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中文名稱：GMDS兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA009569LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) GMDS Polyclonal antibody
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Uniprot No.：
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基因名：GMDS
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別名：GDP D mannose dehydratase antibody; GDP mannose 4 6 dehydratase antibody; GDP-D-mannose dehydratase antibody; GDP-mannose 4,6 dehydratase antibody; GMD antibody; Gmds antibody; GMDS_HUMAN antibody; OTTHUMP00000017756 antibody; OTTHUMP00000232770 antibody; SDR3E1 antibody; Short chain dehydrogenase/reductase family 3E member 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human GDP-mannose 4,6 dehydratase protein (243-346AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
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基因功能參考文獻：
- Data indicate three loci associated with primary open-angle glaucoma (POAG) were located upstream of ATP binding cassette transporter 1 (ABCA1), within actin filament associated protein 1 (AFAP1) and within GDP-mannose 46-dehydratase (GMDS). PMID: 25173105
- These data demonstrate involvement of GMDS mutation in the progression of colorectal cancer. PMID: 23922970
- Fx enzyme and GDP-L-Fuc Tr overexpression in the tumur tissue of colorectal cancer (CRC) patients suggests that GDP-L-Fuc transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC. PMID: 23730929
- GMD inhibits tankyrase 1 poly(ADP-ribose) polymerase activity in vitro, dependent on the GMD tankyrase 1 binding motif. In vivo, depletion of GMD led to degradation of tankyrase 1, dependent on the catalytic PARP activity of tankyrase 1. PMID: 22645305
- Results indicate that GMDS regulates the formation of secondary complex II from the primary DISC independent of direct fucosylation of death receptors. PMID: 22027835
- FX takes part in the cascade of events leading to the extravasation of activated lymphocytes. PMID: 11831876
- Deficiency of GMDS leads to escape from natural killer cell-mediated tumor surveillance through modulation of TRAIL signaling. PMID: 19361506
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蛋白家族：NAD(P)-dependent epimerase/dehydratase family, GDP-mannose 4,6-dehydratase subfamily
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數據庫鏈接：
