GM2A Antibody, HRP conjugated

說明書

中文名稱：

GM2A兔多克隆抗體, HRP偶聯
貨號：

CSB-PA02379B0Rb
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GM2A Polyclonal antibody
Uniprot No.：

P17900
基因名：

GM2A
別名：

Cerebroside sulfate activator protein antibody; ganglioside GM2 activator antibody; Ganglioside GM2 activator isoform short antibody; Ganglioside GM2 activator precursor antibody; GM2 activator antibody; GM2 AP antibody; GM2 ganglioside activator antibody; GM2 ganglioside activator protein antibody; GM2-AP antibody; GM2A antibody; GM2AP antibody; OTTHUMP00000160619 antibody; SAP 3 antibody; SAP-3 antibody; SAP3 antibody; SAP3_HUMAN antibody; Shingolipid activator protein 3 antibody; Sphingolipid activator protein 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ganglioside GM2 activator protein (32-193AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity.
基因功能參考文獻：
1. Review of GM2A mutations causing GM2 activator protein deficiency and GM2 gangliosidosis-AB variant. PMID: 27402091
2. Studies indicate that sphingolipid activator proteins (SAPs) and anionic lipids are essential stimulators to reach physiological rates of lysosomal sphingolipid degradation. PMID: 27157270
3. this study has established the potential role of GM2A in breast cancer progression PMID: 27002480
4. Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies PMID: 26175473
5. Gene polymorphisms of MD2 and GM2A were associated with the occurrence or severity of neonatal necrotizing enterocolitis. PMID: 25816011
6. In vitro assays with the isolated H1 or H2 homodimers (beta-alpha hybrid construct of beta-hexosaminidase A subunits) confirmed that neither was capable of human GM2AP-dependent hydrolysis of GM2 ganglioside. PMID: 23483939
7. impact of GM2AP on glucose metabolism PMID: 21784073
8. Treatment of meniscal explants with IL-1RA inhibited the expression of many catabolic genes following a single bout of high dynamic strain. PMID: 21331553
9. these results provide novel insights into the physiological functions of GM2AP in obesity. PMID: 21036149
10. GM2 activator protein exerts strong and broad inhibitory effects on the hydrolysis of phospholipids carried out by plant and microbial phospholipases D PMID: 12576516
11. Two new structures of GM2-AP with bound lipids, showing two different lipid-binding modes within the apolar pocket PMID: 12909021
12. elucidation of mode of action on gangioside GM2 PMID: 14728689
13. alpha-subunit loop structure is required for GM2 activator protein binding by beta-hexosaminidase A PMID: 15485660
14. glycosphingolipids, particularly GM2, form a complex with CD82, and this complex interacts with Met and thereby inhibits HGF-induced Met tyrosine kinase activity, as well as integrin to Met cross-talk PMID: 17215249
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相關疾病：

GM2-gangliosidosis AB (GM2GAB)
亞細胞定位：

Lysosome.
數據庫鏈接：

HGNC: 4367

OMIM: 272750

KEGG: hsa:2760

STRING: 9606.ENSP00000349687

UniGene: Hs.483873

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