GLRX5 Antibody, FITC conjugated
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中文名稱：GLRX5兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA769767LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) GLRX5 Polyclonal antibody
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Uniprot No.：
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基因名：GLRX5
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別名：C14orf87 antibody; Chromosome 14 open reading frame 87 antibody; FLB4739 antibody; GLRX 5 antibody; Glrx5 antibody; GLRX5_HUMAN antibody; Glutaredoxin 5 homolog antibody; Glutaredoxin related protein 5 antibody; Glutaredoxin-related protein 5 antibody; Glutaredoxin5 antibody; GRX5 antibody; MGC14129 antibody; mitochondrial antibody; Monothiol glutaredoxin-5 antibody; PRO1238 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Glutaredoxin-related protein 5, mitochondrial protein (32-157AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer. Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
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基因功能參考文獻：
- GLRX5 rs1007814 showed a statistically marginally significant difference between cases and controls in genotype frequency (case/control: CC 1:6; CT 112:78; TT 752:505, P=0.049361), but no significant differences in allele distribution [odds ratio (OR)=0.852805]In men, we found a minor difference in the genotype frequency (case/control: CC 0:3; CT 72:36; TT 411:280, P=0.037370) and not in allele distribution (OR=1.142857) PMID: 27893590
- Patients with GLRX5-associated variant nonketotic hyperglycemia had normal development with childhood-onset spastic paraplegia, spinal lesion, and optic atrophy. PMID: 24334290
- crystal structure of GLRX5 revealed a tetrameric organization with the [2Fe-2S] clusters buried in the interior and shielded from the solvent by the conserved beta1-alpha2 loop PMID: 21029046
- Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts PMID: 20364084
- No GLRX5 mutations were found among sixty CSA probands examined PMID: 19731322
- Mutations in GLRX5 is associated with sideroblastic-like microcytic anemia and iron overload PMID: 17485548
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相關(guān)疾?。?/div>Anemia, sideroblastic, 3, pyridoxine-refractory (SIDBA3); Spasticity, childhood-onset, with hyperglycinemia (SPAHGC)亞細胞定位：Mitochondrion matrix.蛋白家族：Glutaredoxin family, Monothiol subfamily數(shù)據(jù)庫鏈接：
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