GLIS3 Antibody, Biotin conjugated

說明書

中文名稱：

GLIS3兔多克隆抗體, Biotin偶聯(lián)
貨號：

CSB-PA839863LD01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GLIS3 Polyclonal antibody
Uniprot No.：

Q8NEA6
基因名：

GLIS3
別名：

GLIS3 antibody; ZNF515 antibody; Zinc finger protein GLIS3 antibody; GLI-similar 3 antibody; Zinc finger protein 515 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Zinc finger protein GLIS3 protein (527-663AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'.
基因功能參考文獻：
1. Data show that loss of zinc finger protein GLIS3 (GLIS3) causes beta-cell death. PMID: 29992946
2. Data did not show any associations of GLI similar 3 protein (GLIS3) gene polymorphisms rs806052, rs143051164, and rs149840771 with carbohydrate metabolism disorders among patients with maturity onset diabetes of the young (MODY) and type 2 diabetes mellitus (DM2) in Russia. PMID: 29606121
3. Individually the rs7020673 and rs10758593 SNPs are not significantly associated with T1DM but seem to interact in the predisposition for this disease. PMID: 28597135
4. Given the role of GLIS3 in transcriptional activation and repression during embryogenesis, in humans, GLIS3 mutations present with multisystem involvement that also includes renal cystic dysplasia, progressive liver fibrosis and osteopenia. Thyroid findings in GLIS3 patients include thyroid aplasia, diminished colloid with interstitial fibrosis at post-mortem.[review] PMID: 28648506
5. GLIS3 polymorphism is not associated with Dermatomyositis /Polymyositis in the Chinese Han population PMID: 28846454
6. we describe the common facial dysmorphism consisting of bilateral low-set ears, depressed nasal bridge with overhanging columella, elongated, upslanted palpebral fissures, persistent long philtrum with a thin vermilion border of the upper lip in a cohort of seven patients with GLIS3 mutations and report the emergence of a distinct, probably recognizable facial gestalt in this group which evolves with age. PMID: 27148679
7. It may play a role in a number of physiological processes controlled by Glis3. PMID: 26147758
8. New findings with GLIS3 phenotype including craniosynostosis, hiatus hernia, atrial septal defect, splenic cyst, and choanal atresia and confirm further cases with sensorineural deafness and exocrine pancreatic insufficiency. PMID: 26259131
9. analysis of a GLIS3 variant that may have a role in resistance to Japanese type 1 diabetes PMID: 23856252
10. The present data suggest that altered expression of the candidate gene GLIS3 may contribute to both type 1 and 2 type diabetes by favouring beta cell apoptosis PMID: 23737756
11. Alleles of single nucleotide polymorphisms in GLIS3 and ADCY5 may confer risk of type 2 diabetes. PMID: 21949744
12. the associations of GLIS3-rs7034200 and CRY2-rs11605924 with fasting glucose, beta cell function, and type 2 diabetes PMID: 21747906
13. Glis3 interacts with Suppressor of Fused (SUFU) PMID: 21543335
14. results demonstrate a major role for GLIS3 in the development of pancreatic beta cells and the thyroid, eye, liver and kidney PMID: 16715098
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相關(guān)疾病：

Diabetes mellitus, neonatal, with congenital hypothyroidism (NDH)
亞細胞定位：

Nucleus.
蛋白家族：

GLI C2H2-type zinc-finger protein family
組織特異性：

In the adult, expressed at high levels in the kidney and at lower levels in the brain, skeletal muscle, pancreas, liver, lung, thymus and ovary.
數(shù)據(jù)庫鏈接：

HGNC: 28510

OMIM: 610192

KEGG: hsa:169792

STRING: 9606.ENSP00000371398

UniGene: Hs.162125

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