GLIPR1 Antibody

說(shuō)明書(shū)

中文名稱：

GLIPR1兔多克隆抗體
貨號(hào)：

CSB-PA009503LA01HU
規(guī)格：

￥440
圖片：
Immunofluorescent analysis of HepG2 cells using CSB-PA009503LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

IHC image of CSB-PA009503LA01HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA009503LA01HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

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產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GLIPR1 Polyclonal antibody
Uniprot No.：

P48060
基因名：

GLIPR1
別名：

CRISP 7 antibody; CRISP7 antibody; GLI pathogenesis related 1 antibody; GLI pathogenesis-related 1 (glioma) antibody; Glioma pathogenesis related protein 1 antibody; Glioma pathogenesis-related protein 1 antibody; GLIP1_HUMAN antibody; GliPR 1 antibody; GLIPR antibody; GLIPR1 antibody; Protein RTVP-1 antibody; RELATED TO TESTIS SPECIFIC; VESPID; AND PATHOGENESIS PROTEINS 1 antibody; RTVP 1 antibody; RTVP1 antibody; Testes specific vespid and pathogenesis protein 1 antibody; testes-specific vespid and pathogenesis protein 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Glioma pathogenesis-related protein 1 protein (22-232AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，GLIPR1 Antibody (CSB-PA009503LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于GLIPR1 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA009503LB01HU	GLIPR1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009503LC01HU	GLIPR1 Antibody, FITC conjugated
Biotin	CSB-PA009503LD01HU	GLIPR1 Antibody, Biotin conjugated	ELISA

克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶點(diǎn)詳情

基因功能參考文獻(xiàn)：
1. Data found that GLIPR1 expression level was low in human bladder cancer tissues. Also, GLIPR1 was shown to inhibit the expression of TPX2. PMID: 28799673
2. High GLIPR1 expression is associated with cisplatin resistance in lung cancer. PMID: 28771580
3. The present study identified GLIPR1 and miR-16 as key components for regulating the proliferation, migration, invasion and cancer-initiating cells in osteosarcoma PMID: 27460987
4. This study reveals a novel pathway that PRMT5/WDR77 regulates GLIPR1 expression to control lung cancer cell growth. PMID: 26988096
5. Overexpression of RTVP-1 in human neural stem cells induced mesenchymal differentiation, whereas silencing of RTVP-1 in glioma stem cells (GSCs) decreased the mesenchymal transformation and stemness of these cells. PMID: 26267319
6. RTVP-1 regulates glioma cell spreading, migration and invasion and that these effects are mediated via interaction with N-WASP and by interfering with the inhibitory effect of hnRNPK on the function of this protein. PMID: 26305187
7. Data indicate that combining adenoviral vector-mediated GLIPR1 gene therap (AdGLIPR1) with radiotherapy may achieve additive or synergistic tumor control in selected prostate and bladder tumors. PMID: 23433894
8. Based on the observed overexpression in AML samples, GliPR1 should be further explored as a potential target for AML PMID: 24008279
9. miR-137 inhibits Glioblastom stem cell self-renewal and promotes their differentiation by targeting RTVP-1 which down-regulates CXCR4. PMID: 23714687
10. GLIPR1 interacts with Hsc70, and GLIPR1 overexpression or Hsc70 knockdown leads to transcriptional suppression of AURKA and TPX2. PMID: 23333597
11. GLIPR1 core structure has a conserved central cavity via which CAP proteins are likely to bind to shared ligands. PMID: 21931216
12. Data show that the expression of GLIPR1 and c-Myc were inversely correlated in prostate cancer. PMID: 22025562
13. RTVP-1 plays a role in the effect of serum response factor on glioma cell migration PMID: 21777672
14. demonstrate that GLIPR1 is a methylation-silenced gene in the acute myeloid leukemia patients PMID: 21922325
15. GLIPR1 expression is downregulated or even lost by promoter methylation in acute myeloid leukemia. PMID: 19483285
16. X-ray data have been collected to beyond 1.9 A resolution from a crystal of GLIPR1 that belonged to the orthorhombic space group P2(1)2(1)2 with average unit-cell parameters a = 85.1, b = 79.5, c = 38.9 A and either a monomer or dimer PMID: 21045302
17. Induction of GliPR expression by HIV-1 was confirmed in P4-CCR5 cells. PMID: 20356381
18. Expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. PMID: 14871827
19. In this study we report the identification and characterization of a novel p53 target gene cluster that includes human RTVP1 (hRTVP-1) together with two GLIPR1L genes (GLIPR1L1 and GLIPR1L2) on human chromosome 12q21 and mouse Rtvp1 PMID: 16714093
20. RTVP-1b is a novel splice variant of human RTVP-1, which was isolated from the U87 glioma cell line PMID: 17825796
21. a role for GLIPR1/RTVP-1 deregulation early in Wilms tumorigenesis. PMID: 18030365
22. GLIPR1 is a proapoptotic tumor suppressor acting through the ROS-JNK pathway. PMID: 18199537
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亞細(xì)胞定位：

Membrane; Single-pass membrane protein.
蛋白家族：

CRISP family
組織特異性：

According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervou
數(shù)據(jù)庫(kù)鏈接：

HGNC: 17001

OMIM: 602692

KEGG: hsa:11010

STRING: 9606.ENSP00000266659

UniGene: Hs.205558

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