GLE1 Antibody
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中文名稱：GLE1兔多克隆抗體
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貨號：CSB-PA700651EA01HU
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規格：￥440
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圖片：
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Immunoprecipitating GLE1 in A549 whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-PA700651EA01HU in A549 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA700651EA01HU (6µg) + A549 whole cell lysate (500µg)
Lane 3: A549 whole cell lysate (20µg) -
Western Blot
Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate
All lanes: GLE1 antibody at 2.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 80, 76 kDa
Observed band size: 80 kDa -
Immunocytochemistry analysis of human melanoma using CSB-PA700651EA01HU at dilution of 1:100 -
Immunocytochemistry analysis of human breast cancer using CSB-PA700651EA01HU at dilution of 1:100 -
Immunofluorescent analysis of MCF-7 cells using CSB-PA700651EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) GLE1 Polyclonal antibody
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Uniprot No.：
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基因名：GLE1
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別名：GLE 1 antibody; GLE1 antibody; GLE1 like protein antibody; GLE1 like RNA export mediator antibody; GLE1 RNA export mediator homolog antibody; GLE1 RNA export mediator like (yeast) antibody; GLE1-like protein antibody; GLE1_HUMAN antibody; GLE1L antibody; hGLE1 antibody; LCCS 1 antibody; LCCS antibody; LCCS1 antibody; Nucleoporin GLE1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Nucleoporin GLE1 protein (141-380AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，GLE1 Antibody (CSB-PA700651EA01HU)，的標記方式是Non-conjugated。對于GLE1 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC, IF, IP
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 IF 1:50-1:200 IP 1:200-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
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基因功能參考文獻：
- Pathogenic variants in the GLE1 gene are rare in Chinese ALS patients. PMID: 29398120
- Data indicate 2 siblings with a homozygous p.I684T mutation in RNA export mediator (GLE1). PMID: 28657126
- These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism. PMID: 29746542
- We identified bi-allelic mutations in GLE1 in two unrelated individuals with motor delays, feeding difficulties, and respiratory insufficiency who survived beyond the perinatal period. Each affected child had missense variants predicted to result in amino acid substitutions near the C-terminus of GLE1 that are predicted to disrupt protein-protein interaction or GLE1 protein targeting. PMID: 28884921
- It was concluded that the amyotrophic lateral sclerosis-linked Gle1-c.1965-2A>C mutation generates a protein isoform capable of both Gle1A- and Gle1B-ascribed functions, and thereby uncoupled from normal mechanisms of Gle1 regulation. PMID: 26776475
- We also suggest that lethal congenital contracture syndrome 1 (LCCS1) and lethal arthrogryposis with anterior horn disease (LAAHD), the two AMC subtypes related to GLE1, do not have sufficient clinical or molecular differentiation to be considered allelic disorders. Rather, GLE1 mutations cause a variable spectrum of AMC severity including a non-lethal variant described herein PMID: 27684565
- Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6. PMID: 26655997
- Role for Gle1A during stress granule formation and translation regulation during environmental stress responses is examined. PMID: 25694449
- We report the identification of the first heterozygous mutations in GLE1 ever found to be associated with amyotrophic lateral sclerosis. PMID: 25343993
- Lethal congenital contracture syndrome 1 and lethal arthrogryposis with anterior horn cell disease are associated with defective Gle1 function during the export of mRNA. [review] PMID: 24275432
- Report documents a requirement for Gle1 self-association during mRNA export and uncover molecular defects underlying a lethal human disease lethal congenital contracture syndrome-1. PMID: 24243016
- Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export. PMID: 22064466
- defective zebrafish GLE1 function in human LCCS1 results in both neurogenic and non-neurogenic defects linked to the apoptosis of proliferative organ precursors PMID: 22357925
- The unique carboxyl-terminal 43 amino acid region of the hGle1B isoform mediates binding to the C-terminal non-phenylalanine- glycine region of the nucleoporin hCG1/NPL1. PMID: 16000379
- Mutations in mRNA export mediator GLE1 result in fetal motoneuron disease. PMID: 18204449
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相關疾病：Lethal congenital contracture syndrome 1 (LCCS1); Lethal arthrogryposis with anterior horn cell disease (LAAHD)
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亞細胞定位：Nucleus. Cytoplasm.; [Isoform 1]: Cytoplasm. Nucleus, nuclear pore complex.
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蛋白家族：GLE1 family
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數據庫鏈接：
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