GH2 Antibody

說明書

中文名稱：

GH2兔多克隆抗體
貨號：

CSB-PA902740
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA902740(GH2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA902740(GH2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: CSB-PA902740(GH2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
其他：

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靶點詳情

產品詳情

Uniprot No.：

P01242
基因名：

GH2
別名：

GH2 antibody; Growth hormone variant antibody; GH-V antibody; Growth hormone 2 antibody; Placenta-specific growth hormone antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human GH2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
基因功能參考文獻：
1. Type 1 diabetic women delivering large for gestational age infants had lower placental GH levels in early pregnancy. PMID: 26589570
2. genetic association studies in populations in Estonia, Czech Republic, and Bashkortostan/Russia: Data suggest an SNP in GH2 (rs2006123) is associated with adult height (not body mass index); A-allele is associated with taller stature. [META-ANALYSIS] PMID: 24035309
3. Maternal serum PGH at 11-13 weeks' gestation is unlikely to be a useful biochemical marker for early prediction of small for gestational age neonates. PMID: 22489624
4. results are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism. PMID: 22387044
5. These results suggest that the normal PGH-IGF-I-IGFBP3 axis in pregnancy is abnormal in Type 1 Diabetic pregnancies. PMID: 22363400
6. early first trimester maternal serum marker for Down syndrome PMID: 19844941
7. The hGH-V promoter activity and the endogenous mRNA expression in human placental choriocarcinoma cell line JAR in the presence of glucose and demethylating genome conditions, were compared. PMID: 20005926
8. GH-V plays a major role in affecting target cells expressing the GH receptor, thus potentially exerting significant GH-like effects on maternal physiology during pregnancy. PMID: 12213191
9. Data show that improved binding affinity of human growth hormone (hGH(v)) results from numerous small contributions distributed broadly over the interface. PMID: 12946357
10. Using a mutagenesis-scanning analysis of 81 single and 32 pairwise double mutations, it is shown that the GHv hormone's two spatially distal receptor binding sites (Site1 and Site2) are allosterically coupled PMID: 15563602
11. results offer the first evidence for a placental role of human placental growth hormone(hPGH) and suggest an autocrine/paracrine role of hPGH in the regulation of trophoblast invasion PMID: 15718272
12. PGH may play a role in the mechanisms of disease in preeclampsia and fetal growth restriction. PMID: 17701665
13. Placental growth hormone (PGH) secretion by BeWo cells is regulated by hormonal factors and adipokines. Elevated insulin and leptin levels might down-regulate PGH secretion. PMID: 18356738
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亞細胞定位：

Secreted.
蛋白家族：

Somatotropin/prolactin family
組織特異性：

Expressed in the placenta.
數據庫鏈接：

HGNC: 4262

OMIM: 139240

KEGG: hsa:2689

STRING: 9606.ENSP00000333157

UniGene: Hs.406754

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