GGA2 Antibody

說明書

中文名稱：

GGA2兔多克隆抗體
貨號：

CSB-PA009385GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9UJY4
基因名：

GGA2
別名：

1200007E24Rik antibody; ADP ribosylation factor binding protein 2 antibody; ADP ribosylation factor binding protein GGA 2 antibody; ADP ribosylation factor binding protein GGA2 antibody; ADP-ribosylation factor-binding protein GGA2 antibody; ARF-binding protein 2 antibody; FLJ20966 antibody; Gamma adaptin related protein 2 antibody; gamma ear-containing antibody; Gamma-adaptin-related protein 2 antibody; GGA 2 antibody; Gga2 antibody; GGA2_HUMAN antibody; Golgi associated gamma adaptin ear containing ARF binding protein 2 antibody; Golgi localized gamma ear containing ARF binding protein 2 antibody; Golgi-localized antibody; KIAA1080 antibody; Vear antibody; VHS domain and ear domain containing protein antibody; VHS domain and ear domain of gamma adaptin antibody; VHS domain and ear domain of gamma-adaptin antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human GGA2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network.
基因功能參考文獻：
1. Study shows that reduced expression of GGA3 resultes in accumulation of endocytosed EGFR within enlarged endosomes. GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth. Finally, GGA2 was upregulated in 30.8% of human hepatocellular carcinomas and 23.3% of colorectal cancers. PMID: 29358589
2. PI4KIIIbeta interaction with the VHS domain of GGA2 affected PI4KIIIbeta localization. PMID: 28289207
3. full length alpha2B-AR associated with GGA2 but not GGA1, its third intracellular loop was found to directly interact with both GGA1 and GGA2. More interestingly, further mapping of interaction domains showed that the GGA1 hinge region and the GGA2 GAE domain bound to multiple subdomains of the loop. PMID: 27901063
4. These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane. PMID: 24407285
5. GGA2 mediates a vital function that cannot be compensated for by GGA1and/or GGA3. PMID: 22291915
6. endocytosis and intracellular transport of memapsin 2, mediated by its cytosolic domain, may involve the binding of GGA1 and GGA2 PMID: 12135764
7. GGA proteins function with the phosphorylated ACDL in the memasin 2-recycling pathway from endosomes to trans Golgi on the way back to the cell surface. PMID: 15615712
8. Results demonstrate that cargo proteins contribute to the recruitment of GGA2 onto membranes and to the formation of GGA-positive clathrin-coated vesicles. PMID: 17451558
9. These results show that the dual roles of PI4P can promote specific GGA targeting and cargo recognition at the trans-Golgi network. PMID: 17494868
10. p56 tightly cooperates with the GGAs in the sorting of cathepsin D to lysosomes, probably by enabling the movement of GGA-containing transport carriers. PMID: 17596511
11. GGA2 is recruited to the trans-Golgi network independently of the other Golgi-localized, gamma-ear-containing, ARF-binding proteins and is required for the efficient sorting of lysosomal enzymes PMID: 18431031
12. GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs. PMID: 19788741
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亞細胞定位：

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein.
蛋白家族：

GGA protein family
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 16064

OMIM: 606005

KEGG: hsa:23062

STRING: 9606.ENSP00000311962

UniGene: Hs.460336

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