GGA1 Antibody, Biotin conjugated

說明書

中文名稱：

GGA1兔多克隆抗體, Biotin偶聯(lián)
貨號：

CSB-PA890911LD01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GGA1 Polyclonal antibody
Uniprot No.：

Q9UJY5
基因名：

GGA1
別名：

4930406E12Rik antibody; ADP ribosylation factor binding protein 1 antibody; ADP ribosylation factor binding protein GGA1 antibody; ADP-ribosylation factor-binding protein GGA1 antibody; ARF binding protein 1 antibody; ARF-binding protein 1 antibody; Gamma adaptin related protein 1 antibody; gamma ear-containing antibody; Gamma-adaptin-related protein 1 antibody; GGA 1 antibody; GGA1 antibody; GGA1 protein antibody; GGA1_HUMAN antibody; Golgi associated gamma adaptin ear containing ARF antibody; Golgi associated gamma adaptin ear containing ARF binding protein 1 antibody; Golgi localized gamma ear containing ARF binding protein 1 antibody; Golgi-localized antibody; OTTHUMP00000028975 antibody; OTTHUMP00000042200 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human ADP-ribosylation factor-binding protein GGA1 protein (1-89AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane. Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network.
基因功能參考文獻(xiàn)：
1. These findings show that the AD-like phenotype of NPC model cells can be partly reverted by promoting a non-amyloidogenic processing of APP through the upregulation of GGA1 supporting its preventive role against AD PMID: 24866237
2. On basis of these results, propose that GGA1 facilitates LR11 endocytic traffic and that LR11 modulates A-beta levels by promoting amyloid-beta precursor protein traffic to the endocytic recycling compartment PMID: 22621900
3. X-ray structure of the GGA1 VHS domain alone, and in complex with the carboxy-terminal peptide of cation-independent mannose 6-phosphate receptor containing an ACLL sequence PMID: 11859376
4. The 2.4-A crystal structure of the GAT domain of human GGA1 reveals a three-helix bundle, with a long N-terminal helical extension that is not conserved in GAT domains that do not bind ARF. PMID: 12668765
5. X-ray crystal structures of the human GGA1-GAT domain and the complex between ARF1-GTP and the N-terminal region of the GAT domain PMID: 12679809
6. Crystal structure of the human GGA1 GAT domain PMID: 12767220
7. A hydrophobic surface patch on the C-terminal three-helix bundle motif of the GGA1 GAT domain is directly involved in binding with a coiled-coil region of rabaptin-5. PMID: 14636058
8. GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region PMID: 14973137
9. Rabaptin-5, ubiquitin, and TSG101 bind to overlapping but distinct binding sites on the trihelical bundle subdomain of GGA-1 protein PMID: 15143060
10. Our data indicate that GGA proteins are not only involved in the sorting at the TGN but also mediate the retrograde transport of cargo proteins from endosomes to the TGN. PMID: 15886016
11. the trafficking of adiponectin through its secretory pathway is dependent on GGA-coated vesicles PMID: 16407204
12. GGA1 prevented APP beta-cleavage products from becoming substrates for gamma-secretase. Direct binding of GGA1 to BACE was not required for these effects, but the integrity of the GAT (GGA1 and TOM) domain of GGA1 was. PMID: 17005855
13. GGA1 alters the proteolytic processing of beta-amyloid precursor protein (APP) and the secretion of APPs and amyloid-beta, suggesting a role of GGA1 in Alzheimer's disease pathogenesis. PMID: 17151287
14. the interaction between the hinge region and the GAE domain underlies the autoregulation of GGA function in clathrin-mediated trafficking through competing with the accessory proteins and the AP-1 complex PMID: 17506864
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亞細(xì)胞定位：

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein.
蛋白家族：

GGA protein family
組織特異性：

Ubiquitously expressed.
數(shù)據(jù)庫鏈接：

HGNC: 17842

OMIM: 606004

KEGG: hsa:26088

STRING: 9606.ENSP00000341344

UniGene: Hs.499158

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