GEMIN2 Antibody, FITC conjugated

說明書

中文名稱：

GEMIN2兔多克隆抗體, FITC偶聯
貨號：

CSB-PA021329LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GEMIN2 Polyclonal antibody
Uniprot No.：

O14893
基因名：

GEMIN2
別名：

Component of gems 2 antibody; Gem (nuclear organelle) associated protein 2 antibody; Gem associated protein 2 antibody; GEMI2_HUMAN antibody; Gemin-2 antibody; gemin2 antibody; SIP 1 antibody; SIP-1 antibody; SIP1 antibody; SIP1 delta antibody; SIP1-delta antibody; SMN interacting protein 1 antibody; SMN interacting protein 1 delta antibody; SMN-interacting protein 1 antibody; Survival interacting protein 1 antibody; Survival of motor neuron protein interacting protein 1 antibody; Survival of motor neuron protein-interacting protein 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Gem-associated protein 2 protein (1-280AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound.
基因功能參考文獻：
1. Specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of human Gemin2. PMID: 27974620
2. The authors propose that Gemin2 is a versatile hub for ribonucleoprotein exchange that functions broadly in RNA metabolism. PMID: 26828962
3. investigate the oligomeric nature of the SMN.Gemin2 complexes from humans and fission yeast (hSMN.Gemin2 and ySMN.Gemin2) PMID: 26092730
4. Two monoclonal antibodies against SMN (survival-of-motor-neurons) protein bind to its site of interaction with gemin2. PMID: 23939045
5. several conserved SMN residues, including the sites of two SMA patient mutations, are not required for binding to Gemin2. Instead, they form a conserved SMN/Gemin2 surface that may be functionally important for snRNP assembly. PMID: 22607171
6. Overexpression of SIP1 and downregulation of E-cadherin is associated with delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy PMID: 21913013
7. purified SMN-GEMIN2 fusion protein enhanced the RAD51-mediated homologous pairing much more efficiently than GEMIN2 alone PMID: 21732698
8. Study identified Gemin2 as the protein that binds a pentamer of Sm proteins comprised of SmD1/D2 and SmF/E/G; the crystal structure of this complex bound to SMN's Gemin2 binding domain to 2.5 A was determined. PMID: 21816274
9. Novel monoclonal antibodies detect SIP1 in the cytoplasm of human cells from multiple tumor tissue arrays. PMID: 20515682
10. This study demonstrated that miR-141 levels correlate inversely with SIP1 protein levels as well as cell migration and invasion of CRC cells; SIP1 was identified as a functional target of miR-141. PMID: 19830559
11. This study supports the rationale for developing SIP1 as a potential therapeutic and diagnostic target for gliomas PMID: 19806322
12. SIP1 appears to stabilize functional multimer forms of IN, thereby promoting the assembly of IN and RT on viral RNA to allow efficient reverse transcription, which is a prerequisite for efficient HIV-1 infection PMID: 19915660
13. Spinal muscular atrophy and amyotropic lateral sclerosis patients have decreased SIP 1-alpha and increased SIP 1-beta expression levels compared to normal tissues. PMID: 11943600
14. SIP1 determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy. PMID: 15964810
15. binds to HIV-1 integrase and facilitates viral cDNA synthesis and subsequent steps that precede integration in vivo PMID: 16731905
16. Gemin2 plays an important role in small nuclear ribonucleoprotein assembly through the stabilization of the survival of motor neuron oligomer/complex via novel self-interaction PMID: 17308308
17. relationship between the feature of gene mutations and single nucleotide polymorphisms of SIP1 gene and HSCR PMID: 18247312
18. We found upregulation of mRNA for transcription factors Snail, Slug, Twist, and SIP1 in spindle cell carcinoma when compared to squamous cell carcinoma. PMID: 19381684
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亞細胞定位：

Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.
蛋白家族：

Gemin-2 family
數據庫鏈接：

HGNC: 10884

OMIM: 602595

KEGG: hsa:8487

STRING: 9606.ENSP00000308533

UniGene: Hs.652307

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