GDI1 Antibody

說明書

中文名稱：

GDI1兔多克隆抗體
貨號：

CSB-PA004641
規(guī)格：

￥1090
圖片：
Western Blot analysis of K562 cells using GDI-1 Polyclonal Antibody
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品描述：

The GDI1 antibody is generated by immunizing rabbits with the synthesized peptide derived from the C-terminal domain of the human GDI1 protein. It is a polyclonal antibody and exists as an unconjugated IgG. It can cross-react with human, mouse, and rat GDI1 protein. And it has undergone affinity purification from rabbit anti-serum by affinity-chromatography using epitope-specific immunogen. Quality tests of this antibody in WB and ELISA have been validated. The target protein GDI1, expressed primarily in neural and sensory tissues, is a regulator of the Rab small G proteins implicated in neurotransmission, and mutations of Rab GDIα cause human X-linked mental retardation associated with epileptic seizures.
Uniprot No.：

P31150
基因名：

GDI1
別名：

1A antibody; FLJ41411 antibody; GDI-1 antibody; gdi1 antibody; GDIA_HUMAN antibody; GDIL antibody; GDP dissociation inhibitor 1 antibody; Guanosine diphosphate dissociation inhibitor 1 antibody; Mental retardation X-linked 41 antibody; Mental retardation X-linked 48 antibody; MRX41 antibody; MRX48 antibody; Oligophrenin 2 antibody; Oligophrenin-2 antibody; OPHN2 antibody; Protein XAP 4 antibody; Protein XAP-4 antibody; Protein XAP4 antibody; Rab GDI alpha antibody; Rab GDP dissociation inhibitor alpha antibody; RABGD1A antibody; RABGDIA antibody; XAP 4 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the C-terminal region of Human GDI-1.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
基因功能參考文獻(xiàn)：
1. Data confirm isolated adrenocorticotropin deficiency (IAD) as autoimmune disease; RABGDIA (human, human recombinant, or rat) exhibits characteristics of autoantigen in anterior pituitary; patients with IAD exhibit autoantibodies against RABGDIA. PMID: 25346144
2. Human oligodendrogliomas cells stably expressing mutant GDI1 showed altered cell proliferation. PMID: 25694352
3. The results of this study identified RabGDI as a component of the switching mechanism that is required for commissural axons to change their response from attraction to repulsion at the intermediate target PMID: 23140504
4. GDI1 mutations cause an unspecific phenotype characterized by cognitive deficits of variable degree in males, and to a lesser degree in female carriers. PMID: 22002931
5. The mutations in this gene are common and do not seem to influence the gene expression so as to cause a change in phenotype. PMID: 21736009
6. A model by which mutant PrP induces overexpression of GDI, activating a cytotoxic feedback loop that leads to protein accumulation in the secretory pathway. PMID: 19996123
7. RhoGDI has a role in inactivating Rho GTPases with ExoS RhoGAP PMID: 15292224
8. isoprenylcysteine carboxylmethyltransferase regulates Rac1 activity by controlling the interaction of Rac1 with RhoGDI through TNFA PMID: 15647276
9. RhoGDI overexpression is associated with paclitaxel resistance in ovarian cancers PMID: 16596196
10. The results of case-control analysis indicated that, no association between the rs11549300 polymorphisms of GDI1 and children NSMR (P >0.05), but its polymorphisms may be related to intelligence levels of children in Qinba region (P =0.03). PMID: 18487148
11. GDI-1 is preferentially involved in insulin-stimulated glucose transporter 4 (GLUT4) translocation through facilitating Rab10 recycling. PMID: 19570034
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相關(guān)疾?。?/div>
Mental retardation, X-linked 41 (MRX41)
亞細(xì)胞定位：

Cytoplasm. Golgi apparatus, trans-Golgi network.
蛋白家族：

Rab GDI family
組織特異性：

Brain; predominant in neural and sensory tissues.
數(shù)據(jù)庫鏈接：

HGNC: 4226

OMIM: 300104

KEGG: hsa:2664

STRING: 9606.ENSP00000394071

UniGene: Hs.595950

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